{"id":"W4307717490","doi":"10.1172/jci163670","title":"Epigenetics in glaucoma: a link between DNA methylation and neurodegeneration","year":2022,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Eye Institute; School of Medicine, Stanford University; National Institutes of Health; Children's Health Research Institute; U.S. Department of Veterans Affairs; American Glaucoma Society; Research to Prevent Blindness","keywords":"Optic nerve; Epigenetics; Neurodegeneration; Haploinsufficiency; Biology; Glaucoma; Normal tension glaucoma; Retinal degeneration; Genetics; DNA methylation; Protein arginine methyltransferase 5; Methyltransferase; Histone; Cell biology; Neuroscience; Methylation; Medicine; Gene; Pathology; Open angle glaucoma; Phenotype; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006902115,0.0004883487,0.0005796647,0.000507398,0.001287451,0.0008361521,0.0004578636,0.01007686,0.002538125],"category_scores_gemma":[0.003073812,0.000258127,0.0003732839,0.0003828605,0.00161101,0.001172763,0.0004561995,0.006193066,0.001424461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110891,"about_ca_system_score_gemma":0.0005731322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008127255,"about_ca_topic_score_gemma":0.001380369,"domain_scores_codex":[0.9996152,0.0001390478,0.0000492682,0.00004523382,0.0000995095,0.00005172426],"domain_scores_gemma":[0.9989028,0.0005851061,0.0001457356,0.0000666861,0.0001530158,0.0001465915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008219794,0.0003105654,0.01405955,0.0005176685,0.00009870458,0.1403313,0.001137896,0.0003559601,0.01410801,0.01579702,0.7156922,0.09676907],"study_design_scores_gemma":[0.000770687,0.0008815256,0.02027523,0.0007365486,0.0001647066,0.2360384,0.001137512,0.002830073,0.005614267,0.04161851,0.6898003,0.0001324095],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01631651,0.01690137,0.0008126969,0.9347599,0.02123247,0.00003778117,0.00005651239,0.0001102191,0.009772665],"genre_scores_gemma":[0.1878098,0.02406775,0.001419694,0.4943943,0.2774189,0.00006533931,0.00005215916,0.00004611796,0.01472593],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01007686,"threshold_uncertainty_score":0.00849086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07509897116984104,"score_gpt":0.3561838916366371,"score_spread":0.2810849204667961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}