{"id":"W4307721860","doi":"10.1016/j.omtn.2022.10.012","title":"Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases","year":2022,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Canada Research Chairs","keywords":"Heteroplasmy; Mitochondrion; RNA interference; RNA; Mitochondrial disease; Mitochondrial DNA; Biology; Disease; Nanocarriers; Pharmacology; Medicine; Bioinformatics; Drug; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001187503,0.001220115,0.001717996,0.0002628406,0.0005086567,0.0001524645,0.0008066978,0.0008893762,0.001975782],"category_scores_gemma":[0.00008667209,0.0009308656,0.002535179,0.0002904752,0.0001819879,0.00001021189,0.0001826506,0.0003410609,0.00009508621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557746,"about_ca_system_score_gemma":0.0008190692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003176916,"about_ca_topic_score_gemma":0.000006162133,"domain_scores_codex":[0.9954128,0.0008127682,0.0008650639,0.001613616,0.0004141316,0.0008816011],"domain_scores_gemma":[0.9976337,0.00006954167,0.0005100818,0.001374813,0.0001043987,0.0003074912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001372159,0.0006081135,8.961252e-7,0.0003914136,0.002295481,0.000150028,0.00007434132,0.00005925835,0.05566246,0.0002000418,0.004231682,0.9349541],"study_design_scores_gemma":[0.002943957,0.004467906,6.418255e-7,0.000106117,0.0007734406,0.0001608661,0.00006291924,0.000005520243,0.002308091,0.0002133174,0.9879388,0.001018461],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004063208,0.9863841,0.004358584,0.00007075955,0.003621747,0.003759146,0.0009576987,0.0001105947,0.0003310372],"genre_scores_gemma":[0.00007617584,0.9812418,0.001006896,0.0005081211,0.00212789,0.003011805,0.007352855,0.0003600041,0.00431444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837071,"threshold_uncertainty_score":0.9993142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03167725872682509,"score_gpt":0.3060960928421305,"score_spread":0.2744188341153054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}