{"id":"W4307743190","doi":"10.1182/blood.2022017079","title":"Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Terry Fox Research Institute","funders":"","keywords":"Cancer research; Leukemia; Biology; Minimal residual disease; Stem cell; Cell cycle; Cell; Cell biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005833957,0.0003739615,0.0006433478,0.0004959993,0.0003900703,0.00006783025,0.0004450676,0.000145543,0.0005129401],"category_scores_gemma":[0.0003252236,0.0003850065,0.0002215713,0.001094491,0.0001396865,0.0002759539,0.0007626407,0.001638899,0.000211552],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.00759967,"about_ca_system_score_gemma":0.006312601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143365,"about_ca_topic_score_gemma":0.00007565256,"domain_scores_codex":[0.996218,0.000315468,0.0005940708,0.0008074252,0.001067917,0.0009971246],"domain_scores_gemma":[0.9980581,0.0005963703,0.0002183073,0.0006201082,0.0001205519,0.0003865765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003887464,0.006794445,0.05072147,0.0004884858,0.001197052,0.01282296,0.004127498,0.001286411,0.9070044,0.000176271,0.003141425,0.008352098],"study_design_scores_gemma":[0.1439252,0.01080568,0.1931109,0.0009603139,0.003617771,0.01465224,0.001534178,0.1208001,0.4971171,0.0004028771,0.009598174,0.003475498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891818,0.00006314445,0.0002941043,0.0003586863,0.0002592432,0.0008619456,0.00007504818,0.0001782766,0.008727792],"genre_scores_gemma":[0.9951807,0.00002148059,0.001259678,0.0002605195,0.0002549629,0.0004683681,0.00005882682,0.000107009,0.002388492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4098873,"threshold_uncertainty_score":0.9998602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706552378939415,"score_gpt":0.2796340491265029,"score_spread":0.2625685253371088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}