{"id":"W4307762010","doi":"10.3389/fphys.2022.966454","title":"An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats","year":2022,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Cardiovascular Medical Research and Education Fund; National Institutes of Health; United Therapeutics Corporation","keywords":"Transcriptome; Proteome; Phenotype; Pulmonary hypertension; Biology; Ventricle; Hypoxia (environmental); Internal medicine; Bioinformatics; Medicine; Endocrinology; Gene; Gene expression; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228935,0.0002681971,0.0002748003,0.0006296866,0.0001542855,0.0002171163,0.000109343,0.000162657,0.0007202214],"category_scores_gemma":[0.000116567,0.000116832,0.0002165709,0.0003148747,0.0001737236,0.0001383344,0.0001742699,0.0002477145,0.000161827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122039,"about_ca_system_score_gemma":0.0001179769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003464195,"about_ca_topic_score_gemma":0.000543377,"domain_scores_codex":[0.9998815,0.000008875467,0.000007708213,0.00003867195,0.00003985622,0.00002332605],"domain_scores_gemma":[0.9998217,0.0000172504,0.00008609191,0.00001209811,0.00002180299,0.00004111454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860467,0.00001214957,0.001961775,0.0000260373,0.00001157067,0.0000920308,0.00001492894,0.00001963399,0.9967697,0.00001530531,0.00001887104,0.0008720197],"study_design_scores_gemma":[0.00002355058,0.0008674636,0.4983212,0.00001651332,0.0001203593,0.001859213,0.0001918814,0.001323965,0.49573,0.0001349438,0.001388627,0.00002220007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950924,0.0007006508,0.002201813,0.00004832462,0.00001363964,0.00001338865,0.001523671,0.00005313367,0.0003528534],"genre_scores_gemma":[0.9911225,0.0007608361,0.004037977,0.00009525841,0.00002289575,0.00005217332,0.002248581,0.00003401928,0.001625712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007202214,"threshold_uncertainty_score":0.002409399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228478248269691,"score_gpt":0.2420422836433744,"score_spread":0.2297575011606774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}