{"id":"W4307763943","doi":"10.20944/preprints202210.0459.v1","title":"Phenylbenzohydrazides Obtained from Isatoic Anhydride Present Anti-Inflammatory Activity <em>in Vivo</em> and <em>in Vitro</em>","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"Fundação Oswaldo Cruz","keywords":"In vivo; In vitro; Extravasation; Nitric oxide; Pharmacology; Chemistry; Dexamethasone; Inflammation; Nitric oxide synthase; Tumor necrosis factor alpha; Biochemistry; Immunology; Medicine; Biology; Internal medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.004001569,0.002793444,0.004077201,0.0007354503,0.0006454273,0.0004384283,0.003532202,0.002673249,0.01455545],"category_scores_gemma":[0.002884785,0.002747579,0.001468235,0.0007741477,0.0006277164,0.0007070758,0.01109199,0.004589353,0.0004182282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001802399,"about_ca_system_score_gemma":0.0006231154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125581,"about_ca_topic_score_gemma":0.002124767,"domain_scores_codex":[0.9837038,0.001826357,0.002877242,0.006477207,0.002461069,0.002654306],"domain_scores_gemma":[0.9884517,0.002800355,0.002211604,0.005221426,0.0003045065,0.001010404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001464958,0.002148832,0.1909899,0.000949638,0.0006994581,0.0004836139,0.001425414,0.0005353887,0.7935177,0.00006011471,0.0002024513,0.007522472],"study_design_scores_gemma":[0.002057283,0.00004838263,0.3549691,0.000629717,0.0002626888,0.00002830989,0.0004138508,0.002312049,0.6172901,0.002163874,0.01724476,0.002579836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827673,0.001707397,0.00004804242,0.0005939682,0.0009885426,0.002011404,0.001442529,0.0008709485,0.009569832],"genre_scores_gemma":[0.992476,0.001638412,0.000369476,0.0001898377,0.001277155,0.001328077,0.0004298589,0.0003219362,0.001969264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1762276,"threshold_uncertainty_score":0.9986215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04476002237730802,"score_gpt":0.279794863173522,"score_spread":0.235034840796214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}