{"id":"W4307771167","doi":"10.1093/g3journal/jkac287","title":"Tra1 controls the transcriptional landscape of the aging cell","year":2022,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Saccharomyces cerevisiae; Transcriptome; Cell biology; Histone acetyltransferase; Gene expression; Regulation of gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074772,0.0004744563,0.0002462432,0.0003064688,0.0002322068,0.0004269376,0.0003321353,0.0002302251,0.00133729],"category_scores_gemma":[0.0001015837,0.0001546142,0.0003046917,0.00021604,0.0002217141,0.0001984535,0.0004148322,0.0004293975,0.000806944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004637639,"about_ca_system_score_gemma":0.0002530348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261774,"about_ca_topic_score_gemma":0.001938326,"domain_scores_codex":[0.9998834,0.000009349692,0.000007107981,0.00005113307,0.00002155436,0.00002732397],"domain_scores_gemma":[0.9998307,0.00001163648,0.00006132182,0.00001817392,0.00002970787,0.00004851214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000440983,0.00000414444,0.0004792676,0.00001409535,0.000002383822,0.0000209936,0.00001245057,0.00003381717,0.9980894,0.00004802807,0.00003655721,0.001214731],"study_design_scores_gemma":[0.00001287282,0.0001605023,0.06421162,0.00001464428,0.00003646183,0.0005621385,0.0001089055,0.002327972,0.9244155,0.0002004214,0.007927968,0.00002100759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790453,0.008425955,0.008114542,0.0001728323,0.00005509477,0.00002105114,0.002102534,0.0004703479,0.001592358],"genre_scores_gemma":[0.9889737,0.001987222,0.002423923,0.00008071851,0.00001852424,0.00002321319,0.002211614,0.0000867975,0.004194316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133729,"threshold_uncertainty_score":0.004473686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008577178280846608,"score_gpt":0.2001716399841117,"score_spread":0.1915944617032651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}