{"id":"W4307775050","doi":"10.1038/s41564-022-01247-0","title":"Evasion of cGAS and TRIM5 defines pandemic HIV","year":2022,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Deutsches Elektronen-Synchrotron; National Health and Medical Research Council; Australian Research Council; National Institute of Allergy and Infectious Diseases; London School of Hygiene and Tropical Medicine; Medical Research Council; European Commission; University College London; University of New South Wales; Wellcome Trust; Diamond Light Source; National Institute for Health and Care Research; Analytical Center for the Government of the Russian Federation; National Institutes of Health; University of Texas at Austin","keywords":"Pandemic; Capsid; Virology; Biology; Innate immune system; Simian immunodeficiency virus; Lineage (genetic); Viral replication; Genome; Virus; Genetics; Immune system; Gene; Coronavirus disease 2019 (COVID-19); Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002603882,0.0001448312,0.0003142077,0.0001634657,0.0002316319,0.000002513041,0.0001970427,0.0003581258,0.001188922],"category_scores_gemma":[0.00006653283,0.0001149136,0.00007443713,0.0001426495,0.0002608865,0.00001956853,0.0003042308,0.0008662579,0.0001571309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000514711,"about_ca_system_score_gemma":0.00008079868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000326775,"about_ca_topic_score_gemma":0.00001932417,"domain_scores_codex":[0.9987438,0.0003762802,0.0002067059,0.0003142359,0.00001955581,0.000339468],"domain_scores_gemma":[0.9994269,0.0002089994,0.00008703621,0.0002093354,0.0000468672,0.0000208844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003787207,0.0001412202,0.02471827,0.00001362574,0.0001553126,0.00001122325,0.0001237791,0.000001371906,0.9498944,0.0004726914,0.02027355,0.003815803],"study_design_scores_gemma":[0.00556265,0.001263837,0.01282044,0.00001295388,0.00007619217,0.002228513,0.0002874476,5.787452e-7,0.1378477,0.0003376772,0.8392951,0.0002669235],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589092,0.03840622,0.000006777061,0.000547534,0.000401915,0.0002504812,0.0008410132,0.00004045281,0.0005963857],"genre_scores_gemma":[0.995428,0.0002890432,0.0000740933,0.0002198558,0.00001470892,0.00003736228,0.001340399,0.00001093247,0.002585578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8190215,"threshold_uncertainty_score":0.9997241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009100381751508537,"score_gpt":0.2535737389140548,"score_spread":0.2444733571625462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}