{"id":"W4307775050","doi":"10.1038/s41564-022-01247-0","title":"Evasion of cGAS and TRIM5 defines pandemic HIV","year":2022,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Deutsches Elektronen-Synchrotron; National Health and Medical Research Council; Australian Research Council; National Institute of Allergy and Infectious Diseases; London School of Hygiene and Tropical Medicine; Medical Research Council; European Commission; University College London; University of New South Wales; Wellcome Trust; Diamond Light Source; National Institute for Health and Care Research; Analytical Center for the Government of the Russian Federation; National Institutes of Health; University of Texas at Austin","keywords":"Pandemic; Capsid; Virology; Biology; Innate immune system; Simian immunodeficiency virus; Lineage (genetic); Viral replication; Genome; Virus; Genetics; Immune system; Gene; Coronavirus disease 2019 (COVID-19); Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000093034,0.0001253581,0.0001157974,0.00009028874,0.0001413617,0.000260308,0.0001866232,0.0003223913,0.0005700046],"category_scores_gemma":[0.0001535223,0.00009139162,0.0001321362,0.00006651699,0.0002965432,0.0001670039,0.000244186,0.0004216022,0.000115366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208707,"about_ca_system_score_gemma":0.0001557189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006389134,"about_ca_topic_score_gemma":0.0008271912,"domain_scores_codex":[0.9999286,0.00001298816,0.000004613443,0.00001584387,0.00001412399,0.00002384552],"domain_scores_gemma":[0.9999499,0.000007793452,0.0000143873,0.000006586885,0.00000488494,0.0000163461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108282,0.0000227582,0.006638917,0.00002883603,0.000006660766,0.0002675891,0.00008857407,0.0002815624,0.9877912,0.0006700881,0.00006151739,0.003931507],"study_design_scores_gemma":[0.00005643032,0.001278566,0.1852594,0.00004278561,0.00006319071,0.008442066,0.000936703,0.006052613,0.7892094,0.001675761,0.006948195,0.00003479958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987676,0.0003371394,0.0002492842,0.0000250348,0.00000220178,0.000004079253,0.00002261162,0.000006546932,0.0005855885],"genre_scores_gemma":[0.9993001,0.0001362592,0.0002968665,0.00003628632,0.000001532092,0.000002404181,0.00003813745,0.000002304466,0.0001860307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006389134,"threshold_uncertainty_score":0.002328038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009100381751508537,"score_gpt":0.2535737389140548,"score_spread":0.2444733571625462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}