{"id":"W4307776247","doi":"10.1001/jamaneurol.2022.3651","title":"Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice","year":2022,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medicine; Genetic testing; Epilepsy; Medical diagnosis; Pediatrics; Retrospective cohort study; Genetic counseling; Health care; Young adult; Internal medicine; Psychiatry; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547571,0.00009519542,0.0001387758,0.00004856273,0.00008215252,0.0000134839,0.0002991783,0.00004856604,0.00005167643],"category_scores_gemma":[0.0001952542,0.0000936278,0.00005067549,0.0000695181,0.00001714299,0.000004320649,0.0004587358,0.00009335767,0.000005097664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008740069,"about_ca_system_score_gemma":0.00003828331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001671556,"about_ca_topic_score_gemma":0.00003393962,"domain_scores_codex":[0.9988109,0.0001939225,0.0003622226,0.0003705436,0.0001355224,0.0001269082],"domain_scores_gemma":[0.9992442,0.00007405175,0.0001571767,0.0003699055,0.00007045705,0.00008418353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005393432,0.009833626,0.6816924,0.000006426085,0.001008744,0.001090355,0.0008158243,0.01712954,0.005378069,0.0001209096,0.001255411,0.2762752],"study_design_scores_gemma":[0.001972074,0.01383437,0.7660514,4.716575e-7,0.00008574336,0.0000480609,0.0007219742,0.0003206018,0.00008483928,0.00003623056,0.2167284,0.0001158648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963728,0.00003108245,0.00002079423,0.00060745,0.0005139518,0.0003439707,0.00007493741,0.000006715921,0.002028288],"genre_scores_gemma":[0.994676,0.00002696116,0.001380824,0.003318266,0.0003040703,0.0001036421,0.00009719002,0.00001321194,0.00007986529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2761594,"threshold_uncertainty_score":0.3818031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03642670649011587,"score_gpt":0.3564262891723587,"score_spread":0.3199995826822428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}