{"id":"W4307776257","doi":"10.1038/s41418-022-01076-y","title":"OPA1 drives macrophage metabolism and functional commitment via p65 signaling","year":2022,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cell biology; Macrophage; Biology; Inflammation; Mitochondrion; Signal transduction; Biochemistry; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216807,0.0003382539,0.0001929168,0.0003496887,0.0002309606,0.000434522,0.0002459089,0.0003526102,0.001555746],"category_scores_gemma":[0.0001175752,0.0001629004,0.0002631159,0.0001666955,0.0004297231,0.000229062,0.0005741871,0.0008784814,0.0005983519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003369576,"about_ca_system_score_gemma":0.0003098589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000625162,"about_ca_topic_score_gemma":0.0008929023,"domain_scores_codex":[0.9997568,0.00003249079,0.00001888344,0.00004222913,0.00005574559,0.00009388405],"domain_scores_gemma":[0.9997999,0.00001950196,0.0000628648,0.00002339504,0.00001895007,0.0000754687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155496,0.00002686564,0.0001796418,0.00002403654,0.000001886327,0.0000440779,0.00001387359,0.0000499876,0.9985539,0.0002150667,0.00003933215,0.0007357279],"study_design_scores_gemma":[0.00002784987,0.0002519324,0.007303697,0.00001763216,0.00001361118,0.0002360795,0.0001225136,0.001305175,0.9858394,0.0003284617,0.00454546,0.000008127963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921704,0.001629326,0.003095961,0.0002433154,0.00003726753,0.00002140162,0.0005937539,0.00009717855,0.002111428],"genre_scores_gemma":[0.9953218,0.000685073,0.000944306,0.00006472643,0.000008219144,0.00003152553,0.0003911612,0.00002183422,0.002531464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555746,"threshold_uncertainty_score":0.005204499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069569444890958,"score_gpt":0.2094599099656564,"score_spread":0.1987642155167469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}