{"id":"W4307777878","doi":"10.1007/s11538-022-01086-4","title":"The Tumor Invasion Paradox in Cancer Stem Cell-Driven Solid Tumors","year":2022,"lang":"en","type":"article","venue":"Bulletin of Mathematical Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; H. Lee Moffitt Cancer Center and Research Institute; University of Alberta; Universities Space Research Association; Moffitt Cancer Center","keywords":"Solid tumor; Stem cell; Cancer research; Cancer stem cell; Biology; Cancer; Chemistry; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001016062,0.0004518453,0.0006257521,0.0005000298,0.0005612385,0.001216828,0.000671234,0.001183088,0.001446561],"category_scores_gemma":[0.003227517,0.0002189866,0.0008896866,0.0003372211,0.001671511,0.001580121,0.001253117,0.001287895,0.0001485858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009371699,"about_ca_system_score_gemma":0.0007094036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253539,"about_ca_topic_score_gemma":0.0007474262,"domain_scores_codex":[0.999559,0.0001897707,0.00001720253,0.00005597896,0.0001283095,0.00004979123],"domain_scores_gemma":[0.9987085,0.000810422,0.0002292214,0.00008259,0.00008678782,0.00008252511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005589664,0.0000397589,0.0009746496,0.0001366837,0.00003507723,0.0005431894,0.000200704,0.2442468,0.00726149,0.7412429,0.001035705,0.004227127],"study_design_scores_gemma":[0.00002105604,0.00005137558,0.0003851354,0.0000212122,0.00001911008,0.0002311748,0.00006207688,0.7342514,0.001134249,0.2615072,0.002297944,0.00001799383],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3076039,0.003622611,0.6338542,0.006585542,0.0002706568,0.00009343611,0.0002525804,0.000215004,0.04750215],"genre_scores_gemma":[0.9746348,0.001064499,0.01931771,0.0002937029,0.00007543512,0.00007863275,0.00004654808,0.00002878285,0.004459855],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001446561,"threshold_uncertainty_score":0.006799638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698676354790062,"score_gpt":0.2919510334352312,"score_spread":0.2649642698873305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}