{"id":"W4307777878","doi":"10.1007/s11538-022-01086-4","title":"The Tumor Invasion Paradox in Cancer Stem Cell-Driven Solid Tumors","year":2022,"lang":"en","type":"article","venue":"Bulletin of Mathematical Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; H. Lee Moffitt Cancer Center and Research Institute; University of Alberta; Universities Space Research Association; Moffitt Cancer Center","keywords":"Solid tumor; Stem cell; Cancer research; Cancer stem cell; Biology; Cancer; Chemistry; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004957906,0.000113774,0.0004437993,0.00005188126,0.00009447738,0.000003677669,0.0001743847,0.00003418528,0.003605778],"category_scores_gemma":[0.00005501397,0.00007218737,0.0001061007,0.0001128663,0.0001967263,0.000002664392,0.0001937814,0.0002483354,0.00006331023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000829228,"about_ca_system_score_gemma":0.00009836705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001206164,"about_ca_topic_score_gemma":0.00001221701,"domain_scores_codex":[0.998736,0.0001566576,0.0004599484,0.0002106938,0.0001637042,0.0002730604],"domain_scores_gemma":[0.9991,0.000384186,0.0001546922,0.0002596547,0.00003025387,0.0000712149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008446196,0.01103408,0.03108739,0.006637279,0.0007592161,0.001091527,0.007256791,0.001128255,0.2916299,0.1525304,0.3092716,0.1791275],"study_design_scores_gemma":[0.00414656,0.002018834,0.001427283,0.0003063529,0.0001694146,0.0002577745,0.003234675,0.0004171121,0.04256142,0.006454054,0.9386135,0.0003929799],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745838,0.002381082,0.00007682443,0.01453608,0.0002176101,0.0007689242,0.00005186486,0.00002747153,0.007356362],"genre_scores_gemma":[0.996453,0.000243013,0.0006137099,0.0007245353,0.00004815436,0.0002721042,0.000006215523,0.000016911,0.001622384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.629342,"threshold_uncertainty_score":0.997305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698676354790062,"score_gpt":0.2919510334352312,"score_spread":0.2649642698873305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}