{"id":"W4307794403","doi":"10.21203/rs.3.rs-2166624/v1","title":"Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; NOMIS Stiftung; Javna Agencija za Raziskovalno Dejavnost RS; International Centre for Genetic Engineering and Biotechnology; Ludwig Institute for Cancer Research; Novartis Foundation; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; Eli Lilly and Company","keywords":"Aminoacylation; Transfer RNA; RNA; C9orf72; Biology; Genetics; Trinucleotide repeat expansion; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058462,0.0003330564,0.0002381994,0.0001820589,0.0001696712,0.0001888882,0.0001336151,0.0003851198,0.001561536],"category_scores_gemma":[0.0001352725,0.00008910234,0.00019399,0.0000857253,0.0002187464,0.00006673027,0.0001534814,0.0003184729,0.0005752035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057497,"about_ca_system_score_gemma":0.00008864139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005260116,"about_ca_topic_score_gemma":0.0004695782,"domain_scores_codex":[0.9998872,0.00002049807,0.000009184649,0.00002992809,0.00003153662,0.00002151448],"domain_scores_gemma":[0.9999235,0.00001642455,0.00002477827,0.0000084925,0.00000758548,0.00001915663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001251865,0.00001042709,0.0002022734,0.00001098939,0.000005462839,0.0002755939,0.000004924591,0.00002242778,0.9988815,0.00002332016,0.00004378772,0.0003940339],"study_design_scores_gemma":[0.00001330088,0.0002546014,0.006017468,0.000003792638,0.00001819014,0.001597019,0.00002314934,0.0006811687,0.9898514,0.00006286952,0.001471808,0.00000521014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996637,0.0007321262,0.001206869,0.0001182285,0.00004525458,0.00000817814,0.0003402215,0.00007712194,0.0008349804],"genre_scores_gemma":[0.9977825,0.0001977153,0.0005091964,0.00003741391,0.00001111489,0.00000734843,0.0002981662,0.00001630751,0.001140249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561536,"threshold_uncertainty_score":0.005223811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05007337762852484,"score_gpt":0.3850348425292365,"score_spread":0.3349614649007117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}