{"id":"W4307810688","doi":"10.1038/s41467-022-34171-2","title":"Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Lundbeckfonden; Celgene; Imperial College London; Danmarks Frie Forskningsfond; Michael Smith Health Research BC; Bristol-Myers Squibb","keywords":"Immunity; Antibody; Virology; Human immunodeficiency virus (HIV); Term (time); CD8; Immunology; Neutralizing antibody; Biology; Medicine; Immune system; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001873789,0.0001501359,0.0003166799,0.0001291419,0.0001339461,0.0002893346,0.0001690253,0.0002158817,0.001129538],"category_scores_gemma":[0.0003445717,0.00008627278,0.0001127216,0.00009806471,0.0001595479,0.0001482805,0.0001358941,0.0006757671,0.0001846676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725146,"about_ca_system_score_gemma":0.0002414051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006376341,"about_ca_topic_score_gemma":0.00124152,"domain_scores_codex":[0.9998577,0.00004115776,0.000009302784,0.00002360027,0.00002820082,0.00003997308],"domain_scores_gemma":[0.9997705,0.00004899938,0.00005182813,0.00003212213,0.00002680886,0.00006977731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002689403,0.000954328,0.006638255,0.00006199601,0.00002251681,0.00009983589,0.00008757309,0.0001429848,0.9578207,0.00008093365,0.0001223347,0.03127921],"study_design_scores_gemma":[0.0004183337,0.03653925,0.2689322,0.00009009751,0.0002056466,0.001300848,0.0002647421,0.003114061,0.6814467,0.0002369309,0.007428718,0.0000223346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983351,0.0005931354,0.0002325335,0.00002738113,0.00001271632,0.00002265421,0.00005791871,0.00002834105,0.0006902632],"genre_scores_gemma":[0.9989711,0.0001381911,0.0002748526,0.00003786343,0.00001070141,0.00001807112,0.0001105606,0.000003162451,0.0004355026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129538,"threshold_uncertainty_score":0.003778696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02695317475193768,"score_gpt":0.3200102441758915,"score_spread":0.2930570694239538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}