{"id":"W4307811795","doi":"10.1101/2022.10.26.513969","title":"Synergistic interactions among <i>Burkholderia cepacia</i> complex (Bcc)-targeting phages reveal a novel therapeutic role for lysogenization-capable (LC) phages","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lysogen; Lysogenic cycle; Biology; Phage therapy; Lytic cycle; Microbiology; Burkholderia cepacia complex; Burkholderia; Bacteriophage; Antibiotic resistance; Virulence; Antibiotics; Prophage; Virology; Bacteria; Genetics; Gene; Escherichia coli; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002326926,0.0003255603,0.0002789528,0.0001771501,0.0001146538,0.0003188931,0.0001473342,0.0002628478,0.0008629005],"category_scores_gemma":[0.0002330145,0.00009999266,0.0002472204,0.0001132568,0.0001807814,0.0001917289,0.0002583518,0.0004325507,0.0002731388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550236,"about_ca_system_score_gemma":0.0001115156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001767445,"about_ca_topic_score_gemma":0.0002274691,"domain_scores_codex":[0.9997732,0.00006417834,0.00001273152,0.00004559919,0.00005012085,0.00005410593],"domain_scores_gemma":[0.9998504,0.00004766174,0.0000379382,0.00001410296,0.00001945695,0.00003049287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000715897,0.00004182941,0.0003683952,0.00002982809,0.000004632852,0.00001515842,0.000007919094,0.0001031021,0.9969313,0.00007463778,0.00004540137,0.002306256],"study_design_scores_gemma":[0.000009969027,0.000842402,0.002561761,0.000007756294,0.00002498839,0.0001585853,0.00002774131,0.00282491,0.9914234,0.00007341099,0.002037815,0.000007279682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864303,0.002461071,0.008833339,0.0001249483,0.00003624273,0.00004308654,0.0000928973,0.0001461307,0.001831977],"genre_scores_gemma":[0.9945568,0.0003976231,0.004330368,0.00005814651,0.000009126978,0.00002438672,0.00006493874,0.00001435872,0.0005443111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008629005,"threshold_uncertainty_score":0.002886653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900691721336455,"score_gpt":0.2384473361975566,"score_spread":0.219440418984192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}