{"id":"W4307823036","doi":"10.1139/cjpp-2022-0277","title":"Effect of nitric oxide–cyclic GMP–K<sup>+</sup> channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apamin; Pharmacology; Glibenclamide; Chemistry; (+)-Naloxone; Channel blocker; Opioidergic; Nitric oxide; Potassium channel; Opioid; Medicine; Endocrinology; Receptor; Biochemistry; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835017,0.0003790265,0.0004774591,0.0001984319,0.000168383,0.0002019239,0.000294744,0.0004312988,0.002359503],"category_scores_gemma":[0.0004148127,0.0002700713,0.0003145042,0.0001251337,0.000309154,0.0004246174,0.0001686627,0.0009686679,0.0004378335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406393,"about_ca_system_score_gemma":0.0003097529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004980243,"about_ca_topic_score_gemma":0.00124825,"domain_scores_codex":[0.9998682,0.00003336552,0.00001296261,0.00001263437,0.0000211344,0.00005177579],"domain_scores_gemma":[0.9996699,0.00009477454,0.00007149449,0.0000225234,0.00003149448,0.0001098777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02374608,0.002196972,0.0007963134,0.0004787847,0.00007761536,0.0003279869,0.0001214637,0.0003405219,0.9566531,0.0001884725,0.0003217739,0.01475091],"study_design_scores_gemma":[0.003229448,0.07207725,0.02519422,0.00008069031,0.0002833273,0.0006095621,0.000291692,0.003038505,0.8906428,0.0001480303,0.004341703,0.00006274622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961384,0.002205411,0.0001762338,0.0001073065,0.00005882032,0.00004276467,0.0001023631,0.00002113882,0.001147649],"genre_scores_gemma":[0.9944582,0.002545771,0.001041075,0.00011807,0.00006176243,0.00007054911,0.0002077112,0.000007702709,0.001489136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359503,"threshold_uncertainty_score":0.007893324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178872560206864,"score_gpt":0.2562198670082801,"score_spread":0.2444311414062114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}