{"id":"W4307831169","doi":"10.1093/brain/awac389","title":"MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"International Progressive MS Alliance; Multiple Sclerosis Society; Canadian Institutes of Health Research; McGill University Health Centre; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; McGill University","keywords":"Neuroinflammation; Experimental autoimmune encephalomyelitis; Blood–brain barrier; Multiple sclerosis; Encephalomyelitis; Immunology; Endothelium; Immune system; Microglia; Medicine; Biology; Pathology; Inflammation; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007543089,0.0002844642,0.000244716,0.0002363105,0.0009496291,0.0002039358,0.0005243457,0.00004709435,0.0008394425],"category_scores_gemma":[0.001991388,0.0003314416,0.0001346259,0.0006598024,0.0000332551,0.0002595695,0.0003149963,0.0002723563,0.0004622696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471421,"about_ca_system_score_gemma":0.0001236449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006473783,"about_ca_topic_score_gemma":0.00000530761,"domain_scores_codex":[0.9960498,0.001150186,0.0005887324,0.0008554767,0.0008059106,0.0005498818],"domain_scores_gemma":[0.998033,0.0009426892,0.0002726461,0.0004599341,0.00004425752,0.0002474206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006302086,0.00004140787,0.000002855384,0.000006744001,0.00000149937,0.00006486298,0.000256801,0.001363418,0.9438573,0.00391883,0.04720477,0.003218497],"study_design_scores_gemma":[0.0009030289,0.0001874483,0.00001056533,0.000003559971,0.000003819209,0.00008006731,0.00003737729,0.003612854,0.7690139,0.0002363922,0.2256549,0.0002560832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729727,0.00001433023,0.00409628,0.01762568,0.001473757,0.001357763,0.001009431,0.0005452358,0.0009048173],"genre_scores_gemma":[0.9301597,0.00001589082,0.0003975863,0.05404884,0.0003831126,0.000463598,0.00009564481,0.0001283008,0.01430735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1784501,"threshold_uncertainty_score":0.9999138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308562120876956,"score_gpt":0.2484808991093673,"score_spread":0.2253952779005978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}