{"id":"W4307831169","doi":"10.1093/brain/awac389","title":"MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"International Progressive MS Alliance; Multiple Sclerosis Society; Canadian Institutes of Health Research; McGill University Health Centre; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; McGill University","keywords":"Neuroinflammation; Experimental autoimmune encephalomyelitis; Blood–brain barrier; Multiple sclerosis; Encephalomyelitis; Immunology; Endothelium; Immune system; Microglia; Medicine; Biology; Pathology; Inflammation; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009537079,0.0003113915,0.0002089403,0.0004772095,0.0002670112,0.0004104119,0.00009619694,0.0002747778,0.002164503],"category_scores_gemma":[0.0001359255,0.0001079249,0.0001402779,0.0001988863,0.0002088323,0.0002137603,0.0002807236,0.0003333941,0.0004711225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801315,"about_ca_system_score_gemma":0.0001489843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030748,"about_ca_topic_score_gemma":0.0004741647,"domain_scores_codex":[0.9998751,0.00002821094,0.000007595885,0.00002553069,0.00002808071,0.00003543274],"domain_scores_gemma":[0.9999291,0.000005869425,0.00002430587,0.000006428995,0.00001483313,0.00001952537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001762912,0.00003400461,0.002595563,0.00008659813,0.00001445262,0.0003133753,0.00006078824,0.00003740896,0.9923462,0.0001954135,0.0001375435,0.004002389],"study_design_scores_gemma":[0.00003534037,0.0005857254,0.1064285,0.00006403411,0.0001048,0.003339061,0.0006676336,0.001937398,0.8701218,0.001071617,0.01562632,0.00001772802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888721,0.004254905,0.003882685,0.000160647,0.00004003791,0.00003730616,0.0003132374,0.00008561728,0.002353461],"genre_scores_gemma":[0.9900676,0.001941926,0.003421045,0.00008894828,0.00005862756,0.00005465972,0.000413583,0.00001274891,0.00394091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164503,"threshold_uncertainty_score":0.007241011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308562120876956,"score_gpt":0.2484808991093673,"score_spread":0.2253952779005978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}