{"id":"W4307838725","doi":"10.1242/dmm.049541","title":"iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Esophageal and GI Pathology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; CHU Sainte-Justine Foundation; Mitacs; Canada Foundation for Innovation","keywords":"Foregut; Induced pluripotent stem cell; Atresia; Biology; SOX2; Esophagus; Endoderm; PAX6; Tracheoesophageal fistula; Stem cell; Pathology; Cell biology; Anatomy; Embryonic stem cell; Medicine; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568139,0.0002686872,0.000247526,0.000327589,0.0001326919,0.0003361318,0.0001155863,0.0003809696,0.002130214],"category_scores_gemma":[0.0001744931,0.0001212475,0.0002954096,0.0001582538,0.0002195335,0.00015221,0.0002203127,0.000517556,0.0006039283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000815477,"about_ca_system_score_gemma":0.00009229608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002025371,"about_ca_topic_score_gemma":0.0002851534,"domain_scores_codex":[0.9998832,0.00001200794,0.00002374559,0.00002756318,0.0000355557,0.00001805827],"domain_scores_gemma":[0.9998751,0.00002913022,0.00003168371,0.0000255075,0.00001254705,0.00002609223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001746726,0.00003109262,0.005010807,0.00006394812,0.0000267051,0.002368903,0.0001088109,0.0001463857,0.9865567,0.0001829471,0.0001201161,0.005208916],"study_design_scores_gemma":[0.00003226159,0.0003173582,0.07351796,0.00003114104,0.00009099673,0.01691238,0.000271707,0.001274226,0.8985859,0.0003034897,0.008648111,0.00001446499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928423,0.0009062572,0.004025573,0.00007379935,0.00003609214,0.00002997084,0.0007298629,0.0001059287,0.001250206],"genre_scores_gemma":[0.9941378,0.0006683598,0.002000679,0.00006175791,0.00001016789,0.00002831304,0.001522209,0.00002805407,0.00154275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002130214,"threshold_uncertainty_score":0.007126272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543474196266239,"score_gpt":0.2387639783466227,"score_spread":0.2233292363839603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}