{"id":"W4307838725","doi":"10.1242/dmm.049541","title":"iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Esophageal and GI Pathology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; CHU Sainte-Justine Foundation; Mitacs; Canada Foundation for Innovation","keywords":"Foregut; Induced pluripotent stem cell; Atresia; Biology; SOX2; Esophagus; Endoderm; PAX6; Tracheoesophageal fistula; Stem cell; Pathology; Cell biology; Anatomy; Embryonic stem cell; Medicine; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001999324,0.0002797221,0.0003545722,0.00008440253,0.0006490625,0.00002303871,0.0002394898,0.00007129369,0.001451433],"category_scores_gemma":[0.00002627715,0.000217461,0.0002386511,0.0001488084,0.00007317347,0.0001408619,0.0004837497,0.0002412035,0.00005033385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002239308,"about_ca_system_score_gemma":0.0001073181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006487132,"about_ca_topic_score_gemma":0.00001787711,"domain_scores_codex":[0.9976406,0.0002476758,0.0003732275,0.0005921278,0.0007213372,0.0004250451],"domain_scores_gemma":[0.9986824,0.00005292112,0.0001811466,0.0006606588,0.00008314542,0.000339709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06777775,0.01476049,0.1949316,0.001620799,0.002537755,0.02090627,0.03688101,0.06342258,0.361748,0.09155234,0.02166127,0.1222001],"study_design_scores_gemma":[0.01298959,0.001859215,0.6471675,0.0001231596,0.0013032,0.00003972128,0.0008467322,0.175805,0.0103028,0.1480829,0.0004409234,0.001039255],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852368,0.0009118473,0.01001429,0.0008030341,0.000388516,0.0009846324,0.001413159,0.0001193694,0.0001283896],"genre_scores_gemma":[0.9907975,0.00001133256,0.0007556166,0.002427367,0.0001349249,0.0002703014,0.001838007,0.00006165098,0.003703315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4522359,"threshold_uncertainty_score":0.9994614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543474196266239,"score_gpt":0.2387639783466227,"score_spread":0.2233292363839603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}