{"id":"W4307838849","doi":"10.1038/s42003-022-04112-2","title":"Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Lawson Health Research Institute; Canadian Diabetes Association","keywords":"Adipogenesis; Bone marrow; Progenitor cell; Diabetes mellitus; Mesenchymal stem cell; Stem cell; Cancer research; Endocrinology; Growth factor; Transforming growth factor beta; Medicine; Cell biology; Transforming growth factor; Internal medicine; Biology; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006289879,0.0001305132,0.0003162324,0.0004276471,0.0003059743,0.00001055728,0.0005808229,0.0001125735,0.0008316325],"category_scores_gemma":[0.0001685459,0.000123896,0.00007379722,0.0007686465,0.0002618238,0.00006971489,0.0004605094,0.0007218723,0.00004491674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002287891,"about_ca_system_score_gemma":0.0001115921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003205753,"about_ca_topic_score_gemma":0.0001449493,"domain_scores_codex":[0.9981706,0.000621933,0.000391959,0.0002467586,0.0001802493,0.0003885019],"domain_scores_gemma":[0.9981026,0.0005383339,0.0000761042,0.001071603,0.0001049416,0.0001063921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001083379,0.0003815274,0.7304077,0.00005697443,0.00007953441,0.000006550281,0.001270149,0.000003842856,0.2508803,0.003759616,0.0001673213,0.01287818],"study_design_scores_gemma":[0.006157808,0.002573041,0.9029133,0.0001119082,0.0001179429,0.00007185109,0.001828825,0.004654491,0.03296179,0.004174152,0.04369437,0.00074057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829139,0.003263007,0.00002626775,0.008816692,0.0001001947,0.0006044029,0.00003602611,0.00008029115,0.004159278],"genre_scores_gemma":[0.9977778,0.0004986546,0.0002977551,0.0001504828,0.00002342779,0.0003270339,0.0005302364,0.00002213887,0.0003724943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2179185,"threshold_uncertainty_score":0.9105793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04861951916607405,"score_gpt":0.3111007563187254,"score_spread":0.2624812371526513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}