{"id":"W4307840105","doi":"10.1093/ibd/izac200","title":"Systematic Review and Meta-analysis: Loss of Response and Need for Dose Escalation of Infliximab and Adalimumab in Ulcerative Colitis","year":2022,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Adalimumab; Infliximab; Medicine; Ulcerative colitis; Internal medicine; Confidence interval; Gastroenterology; Tumor necrosis factor alpha; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001205282,0.0005674373,0.003851537,0.0004222209,0.00008234123,0.0000308741,0.0002261736,0.0002218132,0.00004979606],"category_scores_gemma":[0.001235667,0.0004870189,0.001185807,0.0002734594,0.0003144455,0.00002455829,0.0002749073,0.0001228054,3.517751e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004755984,"about_ca_system_score_gemma":0.0004532339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006049866,"about_ca_topic_score_gemma":0.00004884351,"domain_scores_codex":[0.9951527,0.00188054,0.001753043,0.0006745129,0.0002872162,0.0002520505],"domain_scores_gemma":[0.9970122,0.0004983521,0.001390264,0.0007234983,0.0001733186,0.0002023949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001510664,0.0001117966,0.0003634919,0.9580469,0.0392122,0.0000873336,0.0001000912,0.00001185953,0.000004581722,0.0001577307,0.00004707003,0.0003463095],"study_design_scores_gemma":[0.002053628,0.0002892797,0.0183164,0.01901938,0.9504754,0.00004067164,0.0001986302,0.00003972577,0.000006140658,0.00009930041,0.008319077,0.001142388],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01067004,0.9816062,0.000008206057,0.00001515045,0.00001603356,0.004752282,0.002913791,0.00001019795,0.000008062944],"genre_scores_gemma":[0.006374652,0.9898672,0.0000395464,0.00008005623,0.00001655983,0.002938669,0.0005382319,0.00006145979,0.00008362991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9390275,"threshold_uncertainty_score":0.9997581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623905091264204,"score_gpt":0.3042542270226725,"score_spread":0.2780151761100305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}