{"id":"W4307842003","doi":"10.1200/jco.22.00478","title":"Cost-Effectiveness Analysis of Frontline Polatuzumab-Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone and/or Second-Line Chimeric Antigen Receptor T-Cell Therapy Versus Standard of Care for Treatment of Patients With Intermediate- to High-Risk Diffuse Large B-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Rituximab; Prednisone; Vincristine; Cyclophosphamide; Oncology; Internal medicine; Lymphoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001430986,0.0002614591,0.00356513,0.0005177316,0.00007692299,0.000005280147,0.0001817123,0.000189182,0.0006086233],"category_scores_gemma":[0.0004502982,0.0001718195,0.0005352292,0.0005951693,0.0002564977,0.00005852575,0.000114162,0.0002597938,2.258933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005640804,"about_ca_system_score_gemma":0.001063664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001469668,"about_ca_topic_score_gemma":0.0003436825,"domain_scores_codex":[0.9959841,0.0008028965,0.001898821,0.0003683753,0.0006321149,0.0003136929],"domain_scores_gemma":[0.9922811,0.00386557,0.002109034,0.0003289398,0.001046065,0.0003692508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5491804,0.02163041,0.2852141,0.0001905175,0.004390656,0.00002836785,0.001495084,0.00007270568,0.003028383,0.000001383063,0.00006011027,0.1347079],"study_design_scores_gemma":[0.2607938,0.318003,0.3905113,0.00004981048,0.002115372,0.000002744649,0.001136102,0.0001264028,0.01230465,0.000004294698,0.01480406,0.0001484126],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921377,0.003482363,0.0002033146,0.00008333246,0.0004316132,0.001932102,0.001703931,0.000004961827,0.00002068618],"genre_scores_gemma":[0.9900961,0.007679954,0.001690032,0.00007759999,0.000113983,0.00006508005,0.0001282929,0.00004200455,0.000106968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2963726,"threshold_uncertainty_score":0.7006597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05108753602228596,"score_gpt":0.4074900151700494,"score_spread":0.3564024791477635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}