{"id":"W4307842003","doi":"10.1200/jco.22.00478","title":"Cost-Effectiveness Analysis of Frontline Polatuzumab-Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone and/or Second-Line Chimeric Antigen Receptor T-Cell Therapy Versus Standard of Care for Treatment of Patients With Intermediate- to High-Risk Diffuse Large B-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Rituximab; Prednisone; Vincristine; Cyclophosphamide; Oncology; Internal medicine; Lymphoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004850639,0.001714932,0.002157368,0.001090682,0.0002766517,0.001120834,0.001326893,0.001490016,0.004884867],"category_scores_gemma":[0.01044876,0.0008195341,0.005767748,0.0005847338,0.0006730061,0.001282808,0.0008330687,0.001631137,0.0001778633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006890982,"about_ca_system_score_gemma":0.003610681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01030568,"about_ca_topic_score_gemma":0.006252439,"domain_scores_codex":[0.997479,0.001887087,0.00007778871,0.0001690716,0.0001219896,0.0002650989],"domain_scores_gemma":[0.9938425,0.004551029,0.0007918869,0.0001336647,0.0001715673,0.0005093961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.131552,0.002830515,0.009238171,0.001476287,0.008089409,0.000217362,0.00007483172,0.8088485,0.001056427,0.003067487,0.0009710342,0.03257802],"study_design_scores_gemma":[0.04086793,0.04320752,0.01432053,0.0007176075,0.01493844,0.0003245935,0.0001751156,0.8769598,0.001446788,0.00572477,0.001181909,0.0001350249],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795384,0.005855838,0.007318317,0.0009925995,0.0001487885,0.001280561,0.001446145,0.00009407898,0.003325422],"genre_scores_gemma":[0.9972082,0.0004970771,0.001254058,0.0001307349,0.00001482031,0.0003022517,0.0003196725,0.000005768456,0.0002675114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030568,"threshold_uncertainty_score":0.04999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05108753602228596,"score_gpt":0.4074900151700494,"score_spread":0.3564024791477635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}