{"id":"W4307844453","doi":"10.1038/s41467-022-34179-8","title":"CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université du Québec à Montréal; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"CIHR Skin Research Training Centre; University of Colorado School of Medicine, Anschutz Medical Campus; University of Toronto; Cancer Research Society; Natural Sciences and Engineering Research Council of Canada; Government of Canada; McGill University","keywords":"Melanoma; Cancer research; Mutation; Medicine; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008071325,0.0002912329,0.0002441159,0.000284143,0.0001698891,0.0002159681,0.0001338815,0.0002086687,0.001970938],"category_scores_gemma":[0.00009628495,0.0001294158,0.0001657152,0.0001546822,0.0001632814,0.0001196934,0.000137093,0.0004219755,0.000453138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884628,"about_ca_system_score_gemma":0.0001722779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007676548,"about_ca_topic_score_gemma":0.001107674,"domain_scores_codex":[0.9999084,0.00001409894,0.000007263489,0.0000187733,0.00002982447,0.00002158499],"domain_scores_gemma":[0.999948,0.00000711502,0.00001082594,0.000006451307,0.000005592894,0.0000219567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359815,0.00002479804,0.000241477,0.0000381583,0.000004637885,0.00009050275,0.000005468205,0.00008282331,0.9975938,0.0001211685,0.00008496069,0.001576196],"study_design_scores_gemma":[0.00001764463,0.0002623415,0.00454949,0.000005126888,0.00001032096,0.0007559746,0.00001707925,0.0005944406,0.9885765,0.00007743693,0.0051296,0.000004005341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835476,0.007918349,0.002615542,0.0002158918,0.00009093949,0.00003734161,0.0005886648,0.0002175552,0.00476813],"genre_scores_gemma":[0.9951042,0.001416763,0.0007575072,0.0000328935,0.00001079719,0.00002243514,0.0002967343,0.00001644681,0.002342279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970938,"threshold_uncertainty_score":0.006593466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127229071212058,"score_gpt":0.2631890135558937,"score_spread":0.2519167228437731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}