{"id":"W4307858363","doi":"10.1101/2022.10.31.22281751","title":"Serine/threonine kinase activity associates with brain glucose metabolism changes in Alzheimer’s Disease","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University; McGill University Health Centre","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; IXICO; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Weston Brain Institute; Northern California Institute for Research and Education; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neuroimaging; Voxel; Computational biology; Positron emission tomography; Biology; Neuroscience; Medicine; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002318172,0.0003021527,0.0003627887,0.0009838382,0.0001837473,0.0003766968,0.000150704,0.0002246242,0.001129418],"category_scores_gemma":[0.0004634521,0.0001013913,0.0003878248,0.0008545421,0.000195707,0.0001176123,0.0001787196,0.0002770173,0.0001289856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908494,"about_ca_system_score_gemma":0.0001352942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505765,"about_ca_topic_score_gemma":0.001050961,"domain_scores_codex":[0.999885,0.00002167144,0.00001525196,0.00004450353,0.00001422433,0.00001934797],"domain_scores_gemma":[0.9996752,0.00007978309,0.000139811,0.00001967373,0.00003154843,0.00005408685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002814814,0.0001576642,0.916361,0.0001322274,0.0005114549,0.0005349352,0.000115411,0.0006793524,0.06738084,0.000136232,0.0003130293,0.01086299],"study_design_scores_gemma":[0.000009341698,0.00005385371,0.9960783,0.000004946527,0.0000891581,0.0004238056,0.00004704431,0.001058712,0.001919046,0.000199889,0.0001114777,0.000004426273],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987106,0.0003894563,0.0003908517,0.0000271054,0.000004108308,0.000003619172,0.0003075101,0.00001075961,0.0001558806],"genre_scores_gemma":[0.9991112,0.000113138,0.0003807347,0.00001114111,0.000004635549,0.000004774226,0.0002925063,0.000003067021,0.00007875629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505765,"threshold_uncertainty_score":0.003778279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423150126793838,"score_gpt":0.2508695567391442,"score_spread":0.2366380554712058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}