{"id":"W4307883123","doi":"10.14740/jh1030","title":"Dramatic Response After Switching MEK Inhibitors in a Patient With Refractory Mixed Histiocytosis","year":2022,"lang":"en","type":"article","venue":"Journal of Hematology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Trametinib; Medicine; MEK inhibitor; Erdheim–Chester disease; Langerhans cell histiocytosis; Histiocytosis; Refractory (planetary science); Salvage therapy; Progressive disease; Internal medicine; Disease; Chemotherapy; MAPK/ERK pathway; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003401017,0.0001174468,0.0004788362,0.0004072073,0.00006712719,0.000005556297,0.00005712117,0.00003992995,0.0002096217],"category_scores_gemma":[0.0001641562,0.00008577511,0.0000882159,0.0001990182,0.00003382087,0.00005845259,0.00003750531,0.0003657361,0.000004996578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004549999,"about_ca_system_score_gemma":0.0003329726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002091313,"about_ca_topic_score_gemma":0.00002130145,"domain_scores_codex":[0.9985559,0.0002494606,0.0005555499,0.000119673,0.0003357125,0.000183701],"domain_scores_gemma":[0.999155,0.0001736177,0.0003701363,0.0001404468,0.00006370003,0.00009709574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.1934797,0.01605885,0.4175213,0.0008262828,0.00198048,0.2659691,0.04193339,0.000668295,0.005505362,0.0005039608,0.01323774,0.04231561],"study_design_scores_gemma":[0.1017786,0.08713628,0.1975862,0.005182182,0.003270875,0.3752129,0.05253678,0.001128001,0.007743772,0.003507667,0.1627395,0.002177261],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967368,0.001316407,0.00005486817,0.001308955,0.0002170635,0.000161178,0.000002550802,0.000006496796,0.0001956323],"genre_scores_gemma":[0.9986522,0.000008563345,0.0008840434,0.0003154993,0.00001270266,0.00003691552,0.000001403946,0.00001793059,0.00007079193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2199351,"threshold_uncertainty_score":0.3497807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006383255998476495,"score_gpt":0.2353271983585561,"score_spread":0.2289439423600796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}