{"id":"W4307883123","doi":"10.14740/jh1030","title":"Dramatic Response After Switching MEK Inhibitors in a Patient With Refractory Mixed Histiocytosis","year":2022,"lang":"en","type":"article","venue":"Journal of Hematology","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Trametinib; Medicine; MEK inhibitor; Erdheim–Chester disease; Langerhans cell histiocytosis; Histiocytosis; Refractory (planetary science); Salvage therapy; Progressive disease; Internal medicine; Disease; Chemotherapy; MAPK/ERK pathway; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715766,0.0004629205,0.0005175864,0.0003093707,0.0004603079,0.0004032616,0.0002900029,0.0009293146,0.0004878725],"category_scores_gemma":[0.0006614254,0.0001497196,0.0003156773,0.0002722745,0.0002569378,0.0001811833,0.000210915,0.001221602,0.0002160635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004878776,"about_ca_system_score_gemma":0.0002051833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009827464,"about_ca_topic_score_gemma":0.002127718,"domain_scores_codex":[0.9998692,0.00002575926,0.00001239567,0.00002643065,0.00001788916,0.00004828259],"domain_scores_gemma":[0.9997106,0.00009916166,0.00002515855,0.00001756509,0.00001737506,0.0001300774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.005052159,0.0005324581,0.07489451,0.0001997003,0.0001546704,0.8136671,0.0004957579,0.001413818,0.04538861,0.0002945514,0.002509235,0.05539737],"study_design_scores_gemma":[0.0007594283,0.007159076,0.1733251,0.00007440428,0.0003337951,0.7837808,0.0004270063,0.006335973,0.02006873,0.0006262144,0.00704457,0.00006496096],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928949,0.001814669,0.0006825816,0.001378098,0.00008281197,0.00005442576,0.0001772946,0.00007296688,0.002842154],"genre_scores_gemma":[0.9985539,0.0003247138,0.0002085836,0.0003764521,0.00004675305,0.000006387035,0.0001119228,0.000005870007,0.0003654842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009827464,"threshold_uncertainty_score":0.003539801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006383255998476495,"score_gpt":0.2353271983585561,"score_spread":0.2289439423600796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}