{"id":"W4307888848","doi":"10.1101/2022.10.31.514557","title":"Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology; Takeda Science Foundation","keywords":"Chemistry; GPX4; Biophysics; Lipid peroxidation; Reactive oxygen species; Membrane permeability; Membrane; Biochemistry; Oxidative stress; Programmed cell death; Cell biology; Glutathione; Membrane lipids; Glutathione peroxidase; Catalase; Enzyme; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749534,0.0002548649,0.0002224011,0.0001182629,0.0001221899,0.0002508924,0.0001844417,0.0003589019,0.0009468524],"category_scores_gemma":[0.0001857123,0.0001400476,0.0001777617,0.00006956607,0.000299239,0.0004515777,0.0002310566,0.000692132,0.0001432502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268244,"about_ca_system_score_gemma":0.0001266374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001983275,"about_ca_topic_score_gemma":0.000194431,"domain_scores_codex":[0.9998977,0.00001520905,0.000009223807,0.0000183682,0.00003007665,0.00002945008],"domain_scores_gemma":[0.9998688,0.00002459071,0.00005424611,0.00001075246,0.00001631988,0.00002535452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004231906,0.000005704275,0.0000585387,0.00001189879,0.000001105449,0.0000160354,0.000006069459,0.00001462732,0.9996019,0.00003835274,0.000008418955,0.0001950691],"study_design_scores_gemma":[0.00001480456,0.0001569992,0.003575348,0.000003799846,0.000005696509,0.0001787181,0.00002589463,0.0008946523,0.994356,0.000135131,0.0006488084,0.000004213136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925904,0.001316037,0.004998293,0.0002738871,0.00005721533,0.00003696877,0.00008895485,0.00007358949,0.0005645938],"genre_scores_gemma":[0.9977391,0.0003090399,0.001218543,0.00007039875,0.000009343023,0.00001542536,0.00004395826,0.000008348637,0.000585821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009468524,"threshold_uncertainty_score":0.00316751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853572811465557,"score_gpt":0.2443772680692742,"score_spread":0.2258415399546186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}