{"id":"W4307888848","doi":"10.1101/2022.10.31.514557","title":"Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology; Takeda Science Foundation","keywords":"Chemistry; GPX4; Biophysics; Lipid peroxidation; Reactive oxygen species; Membrane permeability; Membrane; Biochemistry; Oxidative stress; Programmed cell death; Cell biology; Glutathione; Membrane lipids; Glutathione peroxidase; Catalase; Enzyme; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007272477,0.0004866989,0.0007478785,0.0003658664,0.0003735554,0.00007700247,0.000173747,0.0003873043,0.0004945009],"category_scores_gemma":[0.001245519,0.0005093187,0.0001420117,0.0005188613,0.000109244,0.0001178814,0.0005951014,0.0008231407,0.00004375877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456604,"about_ca_system_score_gemma":0.0005310968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002968229,"about_ca_topic_score_gemma":0.000006930717,"domain_scores_codex":[0.9969757,0.0003196145,0.0006106966,0.001250814,0.000438043,0.0004051022],"domain_scores_gemma":[0.9971908,0.0001427384,0.0003431767,0.001168241,0.0007100911,0.0004449127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002736515,0.0002516913,0.02342238,0.0007489513,0.00009403085,0.00001740847,0.00005375118,0.000105198,0.9744799,0.00006489726,0.0004773645,0.00001081729],"study_design_scores_gemma":[0.001399563,0.0006201087,0.8412074,0.0006199257,0.0005514234,4.531891e-7,0.00008410065,0.001585818,0.1437124,0.0000020662,0.00917131,0.001045447],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953216,0.0002795476,0.0005041666,0.001163776,0.000930626,0.001251028,0.0001378723,0.0003927249,0.00001871098],"genre_scores_gemma":[0.9925761,0.0003484112,0.004189795,0.001642738,0.0006976273,0.0004148983,0.000009087184,0.0000994295,0.00002194207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8307675,"threshold_uncertainty_score":0.9997358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853572811465557,"score_gpt":0.2443772680692742,"score_spread":0.2258415399546186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}