{"id":"W4307889735","doi":"10.1093/brain/awac398","title":"Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"National Institutes of Health; Hellenic Foundation for Research and Innovation; Queen's University; Brain and Behavior Research Foundation; Queen's University Belfast; Medical Research Council; Royal Society; Foundation for Research and Technology-Hellas; Wellcome Trust; National Alliance for Research on Schizophrenia and Depression","keywords":"Autism; EIF4E; Knockout mouse; Biology; Gene knockdown; Conditional gene knockout; Translation (biology); Neuroscience; Psychology; Phenotype; Genetics; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002885183,0.0001253281,0.0001093984,0.00005656882,0.0002687038,0.0000172432,0.0001072275,0.00007716215,0.0002837275],"category_scores_gemma":[0.00003555383,0.0001390197,0.00006280628,0.0001059345,0.00007480962,0.000003403073,0.0002162152,0.0001120993,0.00000411916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001718866,"about_ca_system_score_gemma":0.00004100959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004268125,"about_ca_topic_score_gemma":0.000009337129,"domain_scores_codex":[0.9990343,0.0001391522,0.0001704176,0.0003144772,0.0001460308,0.0001956099],"domain_scores_gemma":[0.9995715,0.00001155683,0.00007586485,0.0002408884,0.00001581084,0.00008435662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007396744,0.00007592933,0.0005659455,0.00001285702,0.00004522992,0.00005531423,0.0001036119,0.0005880299,0.9758982,0.0008621664,0.005379359,0.01633937],"study_design_scores_gemma":[0.006301006,0.00140455,0.06226708,0.00007681771,0.0001815812,0.001515621,0.0005054552,0.00453104,0.711496,0.005380532,0.2042526,0.002087734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953027,0.001978165,0.0003384407,0.001457715,0.0001181028,0.0002265406,0.00004821703,0.00003743824,0.0004927308],"genre_scores_gemma":[0.9951534,0.00001077232,0.0001737407,0.0005830487,0.00003971739,0.00004318544,0.0002631541,0.00002463109,0.00370841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2644022,"threshold_uncertainty_score":0.5669057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006630230676631734,"score_gpt":0.2237636753438506,"score_spread":0.2171334446672189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}