{"id":"W4307889735","doi":"10.1093/brain/awac398","title":"Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"National Institutes of Health; Hellenic Foundation for Research and Innovation; Queen's University; Brain and Behavior Research Foundation; Queen's University Belfast; Medical Research Council; Royal Society; Foundation for Research and Technology-Hellas; Wellcome Trust; National Alliance for Research on Schizophrenia and Depression","keywords":"Autism; EIF4E; Knockout mouse; Biology; Gene knockdown; Conditional gene knockout; Translation (biology); Neuroscience; Psychology; Phenotype; Genetics; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004530553,0.000463371,0.00009286142,0.0002408368,0.0001651941,0.0002100647,0.0001205184,0.0001281484,0.0006940459],"category_scores_gemma":[0.000055959,0.0001038297,0.0001275295,0.00007823119,0.0001498124,0.0001447046,0.0001995359,0.0002536246,0.0002151237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002636824,"about_ca_system_score_gemma":0.0001242442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004881525,"about_ca_topic_score_gemma":0.001384846,"domain_scores_codex":[0.9999599,0.000004903136,0.000002734226,0.00001149619,0.00000977058,0.00001109932],"domain_scores_gemma":[0.9999646,0.00000159405,0.00001806447,0.000001975636,0.000005130353,0.000008569653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158907,0.00001008043,0.000628919,0.00002382712,0.000005534704,0.00006580084,0.00001014578,0.00009876831,0.9974995,0.0001663657,0.0000574057,0.001317614],"study_design_scores_gemma":[0.00003445958,0.0001647665,0.08927114,0.00001601376,0.00004171112,0.0007710115,0.0001015113,0.002757534,0.9019844,0.000563358,0.004284016,0.00001014261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956543,0.001475842,0.001141494,0.000104764,0.00001510346,0.000006673572,0.0002513441,0.00007338246,0.00127706],"genre_scores_gemma":[0.9960237,0.0009625591,0.0009839563,0.00002959565,0.000004856608,0.00001426326,0.0002121683,0.00001177627,0.001757215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006940459,"threshold_uncertainty_score":0.00232178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006630230676631734,"score_gpt":0.2237636753438506,"score_spread":0.2171334446672189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}