{"id":"W4307903975","doi":"10.1016/j.fct.2022.113505","title":"BPA exposure in L6 myotubes increased basal glucose metabolism in an estrogen receptor-dependent manner but induced insulin resistance","year":2022,"lang":"en","type":"article","venue":"Food and Chemical Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Institut du Savoir Montfort; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Internal medicine; Endocrinology; GLUT4; Insulin resistance; Insulin; Glucose uptake; Glycogen; Carbohydrate metabolism; Insulin receptor; Chemistry; Glycogen synthase; Glucose homeostasis; Estrogen receptor; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002024016,0.0005980531,0.0005828767,0.0003321214,0.0003545683,0.0004015626,0.0002231001,0.0006028558,0.004257705],"category_scores_gemma":[0.0002103202,0.0003486054,0.0009114757,0.0003976634,0.0003448281,0.0003538612,0.0003495482,0.001527667,0.0008947909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004310252,"about_ca_system_score_gemma":0.0003886913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004394287,"about_ca_topic_score_gemma":0.006508288,"domain_scores_codex":[0.9996676,0.00005137521,0.00003778623,0.00007710567,0.00008608637,0.00008008353],"domain_scores_gemma":[0.9998133,0.00003751631,0.00002319691,0.00002982385,0.00005195893,0.0000441644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001479696,0.0001369055,0.0006911826,0.00006568758,0.00003880164,0.0001449767,0.00004492462,0.00006871288,0.9954189,0.00006647513,0.0002172447,0.001626463],"study_design_scores_gemma":[0.00007181328,0.002596045,0.02354624,0.00001936692,0.00008933123,0.0003416636,0.0002598471,0.0005893531,0.9660863,0.00009838532,0.006279009,0.00002269627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983727,0.002682724,0.004766833,0.0009162331,0.0006141688,0.00007610341,0.002963545,0.0001235398,0.004129824],"genre_scores_gemma":[0.9741578,0.003083059,0.00350712,0.0006195947,0.00009901817,0.0001653448,0.003710499,0.0000633349,0.0145942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004394287,"threshold_uncertainty_score":0.01424348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101609527756566,"score_gpt":0.2753510960910647,"score_spread":0.264335000813499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}