{"id":"W4307906044","doi":"10.1016/j.annepidem.2022.10.014","title":"Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program","year":2022,"lang":"en","type":"article","venue":"Annals of Epidemiology","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Brock University; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Centers for Disease Control and Prevention; Cancer Research Foundation in Northern Sweden; National Institutes of Health; U.S. Department of Health and Human Services; Canada Research Chairs; State of Maryland; Bristol-Myers Squibb; Canadian Institutes of Health Research; American Institute for Cancer Research; Lung Cancer Research Foundation; National Eye Institute; National Institute on Aging; Centre International de Recherche sur le Cancer; European Regional Development Fund; World Health Organization; Institut National Du Cancer; Cancer Research UK","keywords":"Medicine; Biomarker; Malignancy; Lung cancer; Nodule (geology); Etiology; Oncology; Cohort; Cancer; Internal medicine; Cohort study; Prospective cohort study; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.5233421,0.002072319,0.003111173,0.002865083,0.003976644,0.006307063,0.006759576,0.003860456,0.003138968],"category_scores_gemma":[0.5027613,0.002531955,0.005172217,0.003984389,0.005711859,0.002827603,0.008533185,0.005595791,0.001196628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003489859,"about_ca_system_score_gemma":0.01646119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005557299,"about_ca_topic_score_gemma":0.006005619,"domain_scores_codex":[0.3185141,0.6337138,0.01360421,0.01002991,0.02179441,0.002343518],"domain_scores_gemma":[0.4993657,0.3276496,0.02849021,0.09129303,0.04691377,0.00628769],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.05622791,0.005690796,0.156618,0.009520053,0.01442906,0.002814917,0.01048203,0.04394872,0.01845968,0.1799384,0.03001883,0.4718516],"study_design_scores_gemma":[0.02643543,0.04267272,0.1866319,0.005181474,0.0118406,0.002718296,0.003606551,0.1979192,0.02907292,0.2891818,0.2033359,0.001403116],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04318804,0.001610536,0.8494551,0.0100537,0.001930004,0.08362523,0.001495449,0.0007424218,0.007899448],"genre_scores_gemma":[0.08246108,0.000319636,0.7576153,0.003954849,0.0005636041,0.1533341,0.0004784519,0.0001842161,0.001088699],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5233421,"threshold_uncertainty_score":0.5878041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3619237547349349,"score_gpt":0.52003432399084,"score_spread":0.1581105692559051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}