{"id":"W4307910079","doi":"10.1016/s0959-8049(22)01038-3","title":"Targeting acidosis to improve immunotherapy in a pancreatic ductal adenocarcinoma model","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Helix Biopharma (Canada)","funders":"","keywords":"Cancer research; Bicarbonate; Medicine; Pancreatic cancer; Tumor microenvironment; Immunotherapy; Blockade; Combination therapy; Cancer; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279798,0.0003893849,0.0004500806,0.0002219162,0.0002267139,0.0004674626,0.0003726256,0.0006013945,0.001840846],"category_scores_gemma":[0.0001082881,0.0001396092,0.0003702694,0.0002415474,0.0002598798,0.000303228,0.0002645787,0.001755885,0.0002735993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756224,"about_ca_system_score_gemma":0.000434845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005753905,"about_ca_topic_score_gemma":0.0006794792,"domain_scores_codex":[0.9998549,0.00002236815,0.00001115953,0.00003606387,0.00003515632,0.00004026309],"domain_scores_gemma":[0.999911,0.00001156088,0.00002445433,0.00001135078,0.000008006708,0.00003366793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003149905,0.0008710319,0.0006149733,0.0001405105,0.00003674869,0.0001836338,0.000041115,0.001330432,0.9836844,0.0006853499,0.0006171698,0.008644752],"study_design_scores_gemma":[0.0004419195,0.005726958,0.002732851,0.00002333941,0.0001210729,0.0005419264,0.00009019212,0.006326742,0.973033,0.0005835007,0.01036041,0.00001799387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848065,0.00221182,0.007243157,0.001285853,0.0002933378,0.000147839,0.001126382,0.0002263494,0.002658712],"genre_scores_gemma":[0.9889807,0.001720033,0.002948275,0.00023596,0.00004445127,0.0001646991,0.0007371249,0.00003019167,0.005138574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840846,"threshold_uncertainty_score":0.006158292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009070897357579218,"score_gpt":0.2437946523985252,"score_spread":0.234723755040946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}