{"id":"W4307911017","doi":"10.1016/s0959-8049(22)00883-8","title":"Optimal dosing of a novel PLK4 inhibitor nested in a phase II study of CFI-400945 in patients with Advanced/Metastatic Breast Cancer (MBC): Canadian Cancer Trials Group (CCTG) IND.237","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; Ottawa Hospital; University Health Network; Queen's University","funders":"Stand Up To Cancer; Ontario Institute for Cancer Research; Government of Ontario; American Association for Cancer Research","keywords":"Medicine; Neutropenia; Internal medicine; Cancer; Adverse effect; Dosing; Breast cancer; Clinical endpoint; Cohort; Surrogate endpoint; Cmax; Pharmacokinetics; Oncology; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001842436,0.0004284951,0.001709038,0.001215305,0.0001373192,0.00001616124,0.0003843135,0.00002852493,0.0004997833],"category_scores_gemma":[0.0001205027,0.000355817,0.0001572605,0.001587779,0.0001486907,0.0004228734,0.0001268128,0.0008715672,2.394837e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001911131,"about_ca_system_score_gemma":0.001922138,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01841567,"about_ca_topic_score_gemma":0.03865394,"domain_scores_codex":[0.9947074,0.0008458206,0.002217145,0.0004250441,0.001202614,0.0006019565],"domain_scores_gemma":[0.9960546,0.0001100851,0.002407965,0.0003431263,0.0007009433,0.0003833174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06642862,0.01458367,0.3546891,0.0003816658,0.001717534,0.00107025,0.02542443,0.1694562,0.01706414,0.000007014205,0.0001809984,0.3489964],"study_design_scores_gemma":[0.1938683,0.02171438,0.7629085,0.004905363,0.0009717568,0.0001699681,0.01035722,0.0002580187,0.0009446481,0.000004429429,0.003069801,0.0008275863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927105,0.003672752,0.00009566176,0.0004734439,0.0005863589,0.001411295,0.00100559,0.000009640361,0.00003477824],"genre_scores_gemma":[0.9978981,0.0001196825,0.001142687,0.0002565867,0.0002702381,0.0001200926,0.00001312982,0.0001338083,0.00004564995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4082194,"threshold_uncertainty_score":0.9998894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077634545815115,"score_gpt":0.3292102583652843,"score_spread":0.2984339129071331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}