{"id":"W4307911017","doi":"10.1016/s0959-8049(22)00883-8","title":"Optimal dosing of a novel PLK4 inhibitor nested in a phase II study of CFI-400945 in patients with Advanced/Metastatic Breast Cancer (MBC): Canadian Cancer Trials Group (CCTG) IND.237","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; Ottawa Hospital; University Health Network; Queen's University","funders":"Stand Up To Cancer; Ontario Institute for Cancer Research; Government of Ontario; American Association for Cancer Research","keywords":"Medicine; Neutropenia; Internal medicine; Cancer; Adverse effect; Dosing; Breast cancer; Clinical endpoint; Cohort; Surrogate endpoint; Cmax; Pharmacokinetics; Oncology; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001011008,0.0007075844,0.00154266,0.0003741277,0.0002806176,0.001044931,0.0007089032,0.001088136,0.005348466],"category_scores_gemma":[0.0009853988,0.0004356121,0.001050661,0.0003237657,0.0005496843,0.0008586916,0.0003069335,0.002841349,0.0008337835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001145383,"about_ca_system_score_gemma":0.001702307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002547888,"about_ca_topic_score_gemma":0.007996482,"domain_scores_codex":[0.9996706,0.0001335353,0.00001657131,0.00005435104,0.00003371027,0.00009124509],"domain_scores_gemma":[0.9997695,0.00004689472,0.0000424814,0.00001649233,0.00001475343,0.0001098545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7305093,0.01278075,0.002388423,0.0008607966,0.001369512,0.0001024788,0.0001796625,0.003908676,0.01771608,0.0009229461,0.008440619,0.2208208],"study_design_scores_gemma":[0.7934417,0.1829102,0.009067732,0.0001775247,0.0007426167,0.0001597377,0.0001005974,0.002864621,0.002607935,0.0007461015,0.007111961,0.00006941685],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741294,0.009891408,0.001162861,0.0025226,0.0004718352,0.002589504,0.001466715,0.000306156,0.00745959],"genre_scores_gemma":[0.9891624,0.002807203,0.001976686,0.001181034,0.0001400598,0.00100809,0.001089794,0.00003597806,0.002598721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005348466,"threshold_uncertainty_score":0.01789242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077634545815115,"score_gpt":0.3292102583652843,"score_spread":0.2984339129071331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}