{"id":"W4307931719","doi":"10.1038/s41586-022-05374-w","title":"Nociceptor neurons affect cancer immunosurveillance","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Université de Montréal; Université Laval","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; Azrieli Foundation; Canadian Institutes of Health Research; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Cancer Research Society; University of Pennsylvania; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Nociceptor; Immunosurveillance; Calcitonin gene-related peptide; Cytotoxic T cell; CD8; Cancer research; Immunology; Biology; Nociception; Cell biology; Chemistry; Neuropeptide; Medicine; Receptor; Immune system; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001881092,0.0001626772,0.0002918831,0.00009128744,0.0002590648,0.00001596268,0.0001856092,0.000278458,0.002293052],"category_scores_gemma":[0.00009780264,0.0001487424,0.0001752411,0.000345716,0.00005389742,0.00004111956,0.00008292733,0.002530836,0.0000254321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149682,"about_ca_system_score_gemma":0.0002810148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001824191,"about_ca_topic_score_gemma":0.00003609898,"domain_scores_codex":[0.9987276,0.0001453677,0.0001432953,0.0002859326,0.0004049721,0.0002928387],"domain_scores_gemma":[0.9992688,0.0001125801,0.00007458479,0.0004108744,0.00005806155,0.00007506886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009915023,0.0006564977,0.07778465,0.0003647805,0.0004161603,0.0006145343,0.001784197,0.0002401483,0.07480004,0.0002270084,0.7436106,0.08958633],"study_design_scores_gemma":[0.001136281,0.0002905036,0.2009081,0.00002901026,0.000041344,0.0002373916,0.0001570177,0.00003906707,0.001229158,0.000004481798,0.7957717,0.0001559751],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9273489,0.05923665,0.000001710908,0.007904341,0.00218047,0.0004398852,0.0001080072,0.0001479842,0.002632045],"genre_scores_gemma":[0.9822441,0.001024776,0.0000279281,0.004624718,0.0008079784,0.0001538476,0.00005030725,0.00004252821,0.01102378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1231235,"threshold_uncertainty_score":0.9997703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007805237349935568,"score_gpt":0.2873879895623527,"score_spread":0.2795827522124171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}