{"id":"W4307943820","doi":"10.3390/biom12111584","title":"Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Queen's University; Nora Eccles Treadwell Foundation; University of Notre Dame; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Cytoprotection; Antifreeze protein; Cold storage; Cell; Viaspan; Swelling; Hypothermia; Cell damage; Arginine; Antifreeze; Cold-shock domain; Islet; Cryopreservation; Transplantation; Chemistry; Andrology; Biology; Cell biology; Biochemistry; Apoptosis; Medicine; Internal medicine; Endocrinology; Pathology; Insulin; Amino acid; Physiology; Embryo; Horticulture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003133393,0.0002400036,0.0002515794,0.00007306736,0.0002047755,0.00003035829,0.0003250672,0.0001252458,0.00002607178],"category_scores_gemma":[0.0000237142,0.0002626968,0.0001072154,0.0001305612,0.0001312817,0.000003257741,0.0003805761,0.0001323555,0.000003539535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001462085,"about_ca_system_score_gemma":0.0001125485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243233,"about_ca_topic_score_gemma":0.00006021021,"domain_scores_codex":[0.9983948,0.0001501676,0.0003088672,0.0005160228,0.0002906531,0.0003394652],"domain_scores_gemma":[0.9991686,0.00001273013,0.0001819625,0.0004390005,0.00008773264,0.0001099554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004030201,0.0002551586,0.0006403085,0.00009654833,0.00002645158,0.00000924359,0.0003409341,0.00006826353,0.9979119,0.00003454009,0.0002307997,0.0003456018],"study_design_scores_gemma":[0.0007458146,0.0006081446,0.000803665,0.000006390683,0.00003680566,0.000008526093,0.0003120258,0.0001729283,0.9917341,0.00004445253,0.00520825,0.0003189298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889172,0.001505188,0.008147575,0.00008955709,0.000226093,0.0004978213,0.0002101707,0.00001838389,0.0003880133],"genre_scores_gemma":[0.991451,0.0001634287,0.007251885,0.00007588776,0.00008925033,0.00004264636,0.00009654556,0.00005244338,0.0007769269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006177781,"threshold_uncertainty_score":0.9999825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03847502509048738,"score_gpt":0.2425206401590774,"score_spread":0.20404561506859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}