{"id":"W4307943820","doi":"10.3390/biom12111584","title":"Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Queen's University; Nora Eccles Treadwell Foundation; University of Notre Dame; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Cytoprotection; Antifreeze protein; Cold storage; Cell; Viaspan; Swelling; Hypothermia; Cell damage; Arginine; Antifreeze; Cold-shock domain; Islet; Cryopreservation; Transplantation; Chemistry; Andrology; Biology; Cell biology; Biochemistry; Apoptosis; Medicine; Internal medicine; Endocrinology; Pathology; Insulin; Amino acid; Physiology; Embryo; Horticulture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007295083,0.0003530724,0.0001804647,0.0001248426,0.00009264181,0.0001644195,0.0001026093,0.000217807,0.000562467],"category_scores_gemma":[0.00006933963,0.00005401088,0.0001573885,0.00008958011,0.0001056647,0.0001625136,0.0001072936,0.0003689487,0.0001179165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009744816,"about_ca_system_score_gemma":0.0001038943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002894991,"about_ca_topic_score_gemma":0.000568706,"domain_scores_codex":[0.9999621,0.000004901192,0.000003660196,0.00001068297,0.000009898187,0.000008734795],"domain_scores_gemma":[0.9999593,0.000006258274,0.00001426871,0.0000040798,0.000007511117,0.000008472467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002609963,0.000007829973,0.0000462107,0.00002312288,0.000001468646,0.00000763757,0.000004939074,0.00001500097,0.9993381,0.00001180237,0.000007775125,0.0005100337],"study_design_scores_gemma":[0.000003354025,0.0001821405,0.001517132,0.000004993937,0.000008316242,0.00004934813,0.00001126258,0.0001395967,0.9969082,0.00001250264,0.001161444,0.000001736287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930708,0.002836053,0.002995771,0.00007397151,0.00002958348,0.00002303876,0.0001604153,0.00005106208,0.000759256],"genre_scores_gemma":[0.9905285,0.001960838,0.005514808,0.00007196295,0.00001234764,0.00003798269,0.000321901,0.00001578036,0.001535749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000562467,"threshold_uncertainty_score":0.001881599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03847502509048738,"score_gpt":0.2425206401590774,"score_spread":0.20404561506859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}