{"id":"W4307947157","doi":"10.3390/cells11213423","title":"From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pediatric health and respiratory diseases","field":"Health Professions","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lung Foundation Netherlands; Universitair Medisch Centrum Groningen; China Scholarship Council","keywords":"DNA methylation; COPD; Apoptosis; Oxidative stress; Chemistry; DNA damage; Necroptosis; Mitochondrion; Methylation; Cancer research; Immunology; Molecular biology; Biology; Gene expression; Medicine; Programmed cell death; DNA; Biochemistry; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459591,0.0001468953,0.0002578318,0.0002410693,0.0001497813,0.0002276831,0.0001231192,0.0002549666,0.001424738],"category_scores_gemma":[0.0002170151,0.0001278044,0.0002884326,0.0001710687,0.0001462959,0.00009293966,0.0002384298,0.0003238104,0.000236114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530419,"about_ca_system_score_gemma":0.0001279549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009062,"about_ca_topic_score_gemma":0.001650331,"domain_scores_codex":[0.9998237,0.00002472585,0.00001541187,0.00006719447,0.00004376687,0.00002526938],"domain_scores_gemma":[0.9998887,0.00001786606,0.00003568328,0.00001069691,0.00002280413,0.00002436528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002449405,0.00001483862,0.01417461,0.00007787911,0.00003857863,0.00007744598,0.00007772612,0.00004294671,0.9811608,0.00004125583,0.00007665293,0.003972331],"study_design_scores_gemma":[0.00003347394,0.0004667942,0.5935128,0.00005085532,0.0001813658,0.001625467,0.0002646209,0.001118602,0.3983242,0.0003195926,0.004081849,0.00002049627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932303,0.00287034,0.002126518,0.0001559004,0.00002489561,0.0000173738,0.0007941557,0.00005216663,0.0007284278],"genre_scores_gemma":[0.9969208,0.0006598487,0.0007011347,0.0001045164,0.000007958698,0.00002109039,0.000587457,0.00001411952,0.0009831056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424738,"threshold_uncertainty_score":0.004766226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666649623093904,"score_gpt":0.3443235189166757,"score_spread":0.3176570226857366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}