{"id":"W4307947785","doi":"10.3390/biom12111590","title":"Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer","year":2022,"lang":"en","type":"review","venue":"Biomolecules","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"Prostate cancer; Druggability; Androgen receptor; Carcinogenesis; Cancer; Tumor microenvironment; Androgen; Cancer research; Phenotype; Biology; Prostate; Bioinformatics; Medicine; Gene; Internal medicine; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422017,0.0004565667,0.000799797,0.001119385,0.0001592916,0.0007334251,0.0004510505,0.0006217186,0.002807637],"category_scores_gemma":[0.0002501591,0.0001832879,0.0003428347,0.0008180806,0.0002770147,0.0006665406,0.0004495532,0.001132249,0.001674418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003498841,"about_ca_system_score_gemma":0.0004049207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000632803,"about_ca_topic_score_gemma":0.00153426,"domain_scores_codex":[0.9999217,0.00001469557,0.000008692221,0.00001501729,0.00002743011,0.00001250964],"domain_scores_gemma":[0.9999189,0.00003367269,0.00001429802,0.0000030726,0.00002124334,0.000008809063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001400518,0.00006549177,0.0002067261,0.01301951,0.00007651653,0.0002290016,0.00005991121,0.0003997995,0.00706198,0.005131045,0.01861502,0.954995],"study_design_scores_gemma":[0.00001830971,0.0001799966,0.001253724,0.00221429,0.00009939985,0.001302603,0.00005645691,0.0001612742,0.002478584,0.00229957,0.9899158,0.00002001336],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004061609,0.9976923,0.000162187,0.0001895844,0.00008670521,0.000005019303,0.00003239242,0.00001305023,0.001412535],"genre_scores_gemma":[0.002051275,0.9965166,0.0001709554,0.000163004,0.00006463199,0.000007895384,0.00004460056,0.000002463792,0.0009786345],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002807637,"threshold_uncertainty_score":0.0093925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06912333528311727,"score_gpt":0.3923502821749386,"score_spread":0.3232269468918214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}