{"id":"W4307947785","doi":"10.3390/biom12111590","title":"Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer","year":2022,"lang":"en","type":"review","venue":"Biomolecules","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"Prostate cancer; Druggability; Androgen receptor; Carcinogenesis; Cancer; Tumor microenvironment; Androgen; Cancer research; Phenotype; Biology; Prostate; Bioinformatics; Medicine; Gene; Internal medicine; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000213883,0.0004006967,0.001113285,0.0003642747,0.0003146347,0.00009246984,0.0001084137,0.0001197205,0.0001892827],"category_scores_gemma":[0.000058314,0.0002754159,0.0001816247,0.0005062833,0.0001317574,0.00005266301,0.0001787012,0.0002852608,0.000007485125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718142,"about_ca_system_score_gemma":0.0005988931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566072,"about_ca_topic_score_gemma":0.0000719321,"domain_scores_codex":[0.9977515,0.0002126323,0.0004327817,0.0006474821,0.0005022729,0.0004532683],"domain_scores_gemma":[0.9990636,0.00005009761,0.0002038226,0.0003546794,0.00007613772,0.0002516308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007498527,0.0001805199,0.0001065449,0.03637891,0.0004294791,0.0005675163,0.0008514844,4.287031e-7,0.003933589,0.00004238217,0.0003352351,0.9564241],"study_design_scores_gemma":[0.001057068,0.000326135,0.0002385051,0.01006091,0.0006497678,0.0000575109,0.000559168,0.000001009911,0.003350434,0.00000868273,0.9833425,0.0003483166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007951018,0.98778,6.168785e-7,0.0004118464,0.0001207192,0.003142735,0.0003424859,0.00007975187,0.0001707911],"genre_scores_gemma":[0.0004824133,0.9912388,0.0002349703,0.00002437325,0.0001294485,0.003278686,0.0003290628,0.00007991624,0.004202274],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830073,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06912333528311727,"score_gpt":0.3923502821749386,"score_spread":0.3232269468918214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}