{"id":"W4307970770","doi":"10.1158/1078-0432.ccr-21-3577","title":"Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and <i>BRCA1, BRCA2</i> , or <i>ATM</i> Alterations Identified by Testing Circulating Tumor DNA","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Juravinski Cancer Centre; Institute of Cancer Research","funders":"Medical Research Council; National Institute for Health and Care Research; AstraZeneca","keywords":"Olaparib; Medicine; Enzalutamide; Hazard ratio; Internal medicine; Oncology; Cohort; Prostate cancer; Population; Cancer; Confidence interval; Progression-free survival; PARP inhibitor; Chemotherapy; Poly ADP ribose polymerase; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005414671,0.0002916091,0.000535954,0.0002423137,0.0001162659,0.0004615478,0.0002656836,0.0001813242,0.0006785192],"category_scores_gemma":[0.0008380185,0.0001335572,0.000341244,0.0002376862,0.0001845674,0.0002099487,0.0001863757,0.0004624883,0.00009452308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003792961,"about_ca_system_score_gemma":0.0004853191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005327229,"about_ca_topic_score_gemma":0.00183172,"domain_scores_codex":[0.9997608,0.00009671861,0.00002117324,0.00004537799,0.00005077482,0.00002507775],"domain_scores_gemma":[0.9995267,0.0001227314,0.0001500046,0.00002404186,0.00002628979,0.0001501824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1634068,0.004377623,0.6406936,0.0004837765,0.001991133,0.0007516029,0.0002456364,0.002512346,0.02492645,0.0001661031,0.001634749,0.1588101],"study_design_scores_gemma":[0.02113343,0.09302488,0.8710154,0.0001056225,0.00119096,0.002537422,0.000235199,0.002827984,0.004206134,0.000267279,0.003417221,0.00003846493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976794,0.001514559,0.00006462496,0.00004097928,0.000007285973,0.00004348611,0.0001784955,0.000007008489,0.0004641578],"genre_scores_gemma":[0.9991946,0.000257513,0.0001159166,0.00006087721,0.00001433128,0.00001459394,0.0002475656,9.960366e-7,0.00009363871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006785192,"threshold_uncertainty_score":0.002863586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1885218549173735,"score_gpt":0.46875579997178,"score_spread":0.2802339450544065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}