{"id":"W4307976336","doi":"10.1002/ana.26543","title":"Synaptic Loss in Frontotemporal Dementia Revealed by [ <scp> <sup>11</sup> C </scp> ] <scp>UCB‐J Positron Emission Tomography</scp>","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Dementias Platform UK; Medical Research Council Canada; Patrick Berthoud Charitable Trust; National Institute for Health and Care Research; University of Cambridge; Department of Health and Social Care; UCB Pharma; NIHR Cambridge Biomedical Research Centre; Wellcome Trust","keywords":"Frontotemporal dementia; Neuroscience; Magnetic resonance imaging; Psychology; Frontal lobe; Temporal lobe; Dementia; Posterior cingulate; Frontotemporal lobar degeneration; Medicine; Positron emission tomography; Audiology; Internal medicine; Cognition; Radiology; Disease; Epilepsy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004544747,0.0005736251,0.0002783967,0.0008322072,0.0004206604,0.000441037,0.0002403505,0.0004885829,0.00115886],"category_scores_gemma":[0.0006112191,0.0003232315,0.0002007372,0.0003151165,0.0004539493,0.0002115872,0.0003111796,0.0002447503,0.0001869657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355699,"about_ca_system_score_gemma":0.0001960963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008018925,"about_ca_topic_score_gemma":0.01036619,"domain_scores_codex":[0.9999002,0.00002956198,0.00001009879,0.00002524322,0.00001951583,0.00001523293],"domain_scores_gemma":[0.9998583,0.00002456538,0.00004802022,0.00001380505,0.00001680856,0.00003851478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003606442,0.0002331574,0.9524696,0.0001027554,0.000238447,0.002739674,0.0005489683,0.00025596,0.03175796,0.00008043653,0.0002143124,0.007752436],"study_design_scores_gemma":[0.00002376827,0.0003398773,0.9952379,0.000006926784,0.00004143881,0.003017802,0.0001604838,0.0002822858,0.0006925377,0.00009747621,0.00009532621,0.00000407886],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995494,0.0001734692,0.0000619053,0.00000786315,0.000001131829,0.000004466091,0.00005638229,0.000003015365,0.0001422845],"genre_scores_gemma":[0.9996787,0.00004873801,0.0001066791,0.000008070355,0.000001448107,0.000003690891,0.00007126755,6.326063e-7,0.0000807695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008018925,"threshold_uncertainty_score":0.01594448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811264371881379,"score_gpt":0.3056430763154463,"score_spread":0.2775304325966326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}