{"id":"W4307984005","doi":"10.3390/ijms232113261","title":"Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; National Natural Science Foundation of China","keywords":"Abcg2; Pharmacology; Topotecan; Multiple drug resistance; Efflux; Chemistry; In vivo; ATP-binding cassette transporter; Transporter; Chemotherapy; Medicine; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417664,0.0002799885,0.0002149822,0.0001917607,0.00009597502,0.0001400126,0.0002268984,0.0002004549,0.0007914939],"category_scores_gemma":[0.0000890766,0.00007738623,0.0002046967,0.0001542405,0.0001068895,0.000197312,0.0001121397,0.0002577188,0.0002351825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365579,"about_ca_system_score_gemma":0.0002222652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008947098,"about_ca_topic_score_gemma":0.001084126,"domain_scores_codex":[0.999947,0.000009097324,0.000004894784,0.00001250227,0.00001472225,0.00001181896],"domain_scores_gemma":[0.9999619,0.00000429577,0.000007669424,0.000004824487,0.00001044088,0.00001092816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212299,0.00009349625,0.0002066707,0.00003937704,0.000009723244,0.00003898976,0.00001173194,0.000305842,0.9935376,0.00006227225,0.00005546527,0.005517528],"study_design_scores_gemma":[0.00009010642,0.002733811,0.00321374,0.000007012789,0.00004939054,0.0005000299,0.00001222751,0.001908807,0.9866779,0.00003349633,0.004764355,0.000009164037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893271,0.004065397,0.004272523,0.00007959479,0.0000160118,0.0001582273,0.000383981,0.00005277255,0.001644436],"genre_scores_gemma":[0.9925001,0.001203147,0.004167746,0.00005028594,0.000006652824,0.00003555199,0.0007076412,0.000006653338,0.001322137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008947098,"threshold_uncertainty_score":0.002647817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005630672304588578,"score_gpt":0.2428840574426985,"score_spread":0.23725338513811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}