{"id":"W4307994183","doi":"10.3389/fneur.2022.961842","title":"The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Ferritin; TREM2; Microglia; Neurodegeneration; Cerebrospinal fluid; Biomarker; Neuroinflammation; Medicine; Internal medicine; Alzheimer's disease; Dementia; Neuroscience; Endocrinology; Pathology; Disease; Psychology; Chemistry; Inflammation; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003912197,0.00032754,0.0003072016,0.000891591,0.0005163616,0.0005483112,0.0003258661,0.0004458759,0.00164468],"category_scores_gemma":[0.001240963,0.0002080584,0.0002558402,0.0007650164,0.0002878412,0.0003170312,0.0005194957,0.0005156219,0.0002254256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342562,"about_ca_system_score_gemma":0.0001826557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003613576,"about_ca_topic_score_gemma":0.004459264,"domain_scores_codex":[0.9997603,0.00004497831,0.00002810529,0.00009087567,0.00003680375,0.00003892392],"domain_scores_gemma":[0.9991333,0.00009683412,0.0004405482,0.00006404093,0.0001099766,0.0001553221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009266441,0.00007309646,0.9952208,0.00001133301,0.00005313019,0.0002725364,0.0001551383,0.00002915534,0.001771055,0.00003609855,0.0001025164,0.001348514],"study_design_scores_gemma":[0.00001061116,0.0000726597,0.9991007,0.000003373,0.00002040585,0.0003445648,0.0001016356,0.0001108723,0.0001061816,0.00006627683,0.00006001767,0.000002749501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996688,0.00005606184,0.00002564308,0.00001495605,0.000001637257,0.000002339878,0.00009162362,0.000001698294,0.00013715],"genre_scores_gemma":[0.9995723,0.00003068243,0.00005079168,0.000008488952,0.000005186135,0.000003256636,0.00016779,0.000001181917,0.0001602117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613576,"threshold_uncertainty_score":0.007185102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071430861504594,"score_gpt":0.2289275570943189,"score_spread":0.2082132484792729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}