{"id":"W4308025567","doi":"10.1038/s41598-022-22744-6","title":"Meta-analysis of epigenome-wide association studies of major depressive disorder","year":2022,"lang":"en","type":"review","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Epigenome; Differentially methylated regions; Major depressive disorder; DNA methylation; Epigenetics; Internal medicine; Methylation; Biology; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009236171,0.001811524,0.004968259,0.003942007,0.0007165587,0.002025888,0.001273162,0.001372746,0.002680018],"category_scores_gemma":[0.01477503,0.001021335,0.02201259,0.006057364,0.0004419201,0.0007177506,0.001403849,0.001650653,0.0002183259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006759698,"about_ca_system_score_gemma":0.0008604644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005663001,"about_ca_topic_score_gemma":0.008026143,"domain_scores_codex":[0.9913849,0.005035814,0.0009241096,0.001840793,0.000508478,0.0003060785],"domain_scores_gemma":[0.9906148,0.006522658,0.0008900834,0.001291305,0.0004469018,0.0002344023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003808804,0.00004053041,0.179889,0.006893255,0.7902603,0.000441554,0.00008081601,0.003776945,0.003701502,0.0003988152,0.001171821,0.009536627],"study_design_scores_gemma":[0.0005708666,0.0004582086,0.1680159,0.0008988713,0.8186074,0.000478839,0.0001229248,0.004954646,0.00148066,0.001337349,0.00302427,0.00004997908],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4712527,0.4832717,0.02752963,0.002206474,0.001124401,0.0002343754,0.01218361,0.0005578019,0.001639362],"genre_scores_gemma":[0.9728703,0.01977007,0.004107186,0.0004834023,0.0001627055,0.0001532374,0.002024378,0.00007390681,0.0003548092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009236171,"threshold_uncertainty_score":0.04884613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1044019338028076,"score_gpt":0.3641095505218022,"score_spread":0.2597076167189946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}