{"id":"W4308027679","doi":"10.1001/jamaoncol.2022.5357","title":"Interplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19","year":2022,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"COVID-19 and healthcare impacts","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Loxo Oncology; EMD Serono; Genentech; Bausch Health; Ipsen; European Society for Medical Oncology; Astellas Pharma; Eisai; National Institutes of Health; Regeneron Pharmaceuticals; Natera; National Geographic Society; UroGen Pharma; ECOG-ACRIN Cancer Research Group; Seagen; Hope Foundation; Flatiron Health; Vanderbilt University; Advanced Accelerator Applications; National Cancer Institute; Gilead Sciences; Pfizer; Incyte; American Cancer Society; American College of Radiology Imaging Network; Exelixis; Sanofi; American Association for Cancer Research; Amgen; Bristol-Myers Squibb; AstraZeneca","keywords":"Medicine; Interquartile range; Immunosuppression; Cytokine storm; Internal medicine; Cancer; Intensive care unit; Regimen; Retrospective cohort study; Nivolumab; Immunotherapy; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117634,0.00009291765,0.0003122123,0.000118041,0.0001366626,0.000005354705,0.00005135603,0.00007973484,0.0005108491],"category_scores_gemma":[0.0001231999,0.00006991211,0.00002026554,0.0001035562,0.0001671277,0.0000568854,0.000111886,0.000272382,2.670954e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004828326,"about_ca_system_score_gemma":0.0008596563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004811901,"about_ca_topic_score_gemma":0.0004386071,"domain_scores_codex":[0.9991676,0.0001164918,0.0001998865,0.0001836458,0.0001618999,0.0001705216],"domain_scores_gemma":[0.999192,0.0002591397,0.00015347,0.0001511975,0.0000621696,0.0001820083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005117328,0.0002680049,0.9025509,0.0002075124,0.00006831551,0.00003313902,0.004718921,0.000009200845,0.001263548,0.0000290936,0.003352869,0.0823811],"study_design_scores_gemma":[0.008103858,0.004909841,0.8526096,0.00005586208,0.00003283577,0.00003442873,0.0005705665,0.00005087423,0.0001060752,0.00003678138,0.1334139,0.00007547155],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875607,0.001368003,0.00002949311,0.01015115,0.0001334636,0.0004352688,0.00005061701,0.0000171083,0.0002541318],"genre_scores_gemma":[0.988865,0.0004661594,0.00007917796,0.01026206,0.00003267952,0.00006962936,0.00002375361,0.00001418245,0.0001873434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.130061,"threshold_uncertainty_score":0.7274187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175855064826714,"score_gpt":0.3903224077173232,"score_spread":0.3685638570690561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}