{"id":"W4308039771","doi":"10.1016/j.chom.2022.10.004","title":"Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Genome Canada; Canada Research Chairs; Canadian Institute for Advanced Research; Merck","keywords":"Candida albicans; Biology; Corpus albicans; Microbiology; Lipid signaling; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006922228,0.0001863584,0.0002886124,0.00007954711,0.0005277914,0.0000160125,0.0002228103,0.0001044961,0.0009280784],"category_scores_gemma":[0.000177794,0.0001472993,0.000151076,0.0002682936,0.0001926281,0.00008696146,0.0001801942,0.0003746517,0.000009495699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919709,"about_ca_system_score_gemma":0.0002674678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002661381,"about_ca_topic_score_gemma":0.0002973653,"domain_scores_codex":[0.9979488,0.0006709316,0.0003579881,0.0004080064,0.000340317,0.0002739166],"domain_scores_gemma":[0.9986122,0.0001613054,0.0002122898,0.0007815103,0.0001204543,0.0001122966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001839425,0.0005223051,0.0669136,0.000124602,0.000009485634,0.00001923295,0.000679888,0.00003323978,0.9168921,0.000003140439,0.01275609,0.0002069159],"study_design_scores_gemma":[0.001034683,0.001099156,0.1250068,0.00006469651,0.00006898798,0.000009384988,0.000372968,0.00002562583,0.8385611,0.0000105571,0.0336003,0.0001457736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976293,0.0004032469,0.00009806425,0.0002627356,0.0002215669,0.000592279,0.0002298049,0.00004361272,0.0005193761],"genre_scores_gemma":[0.9954207,0.00001783407,0.00006344942,0.0005492534,0.000073907,0.00003119805,0.0002069343,0.00003271656,0.003604012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07833102,"threshold_uncertainty_score":0.9999852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228283942049933,"score_gpt":0.2707723709452822,"score_spread":0.2584895315247828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}