{"id":"W4308039777","doi":"10.1016/j.celrep.2022.111578","title":"The Rb/E2F axis is a key regulator of the molecular signatures instructing the quiescent and activated adult neural stem cell state","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Ottawa","funders":"University Research Board, American University of Beirut; Canadian Institutes of Health Research; Conseil National de la Recherche Scientifique; Fonds De La Recherche Scientifique - FNRS; Forskningsrådet för Arbetsliv och Socialvetenskap; Hospital for Sick Children; Fonds Léon Fredericq; University of Ottawa; American University of Beirut","keywords":"E2F; Neurogenesis; Regulator; Neural stem cell; Cell biology; Cell fate determination; Biology; Cell cycle; Stem cell; Transcription factor; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275726,0.0001477253,0.0001139054,0.00001156666,0.0004695644,0.00003974387,0.0002587818,0.00005518765,0.000004660897],"category_scores_gemma":[0.0000194176,0.00008577406,0.0001092415,0.00009432914,0.0001231016,0.000002119214,0.0005546701,0.0002068234,8.271607e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000218028,"about_ca_system_score_gemma":0.00008779199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004285709,"about_ca_topic_score_gemma":0.00001205372,"domain_scores_codex":[0.9988363,0.0001132576,0.0003231463,0.0002945527,0.0002234041,0.0002092984],"domain_scores_gemma":[0.9987059,0.00001859084,0.0004552964,0.0007002516,0.00008026678,0.00003966425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002925468,0.00002617001,0.001044979,0.0000286134,0.00003356261,0.00001831275,0.0005240164,0.001814116,0.9945857,0.00001814556,0.0004470767,0.001430069],"study_design_scores_gemma":[0.0001791122,0.00008630395,0.001205961,0.000005455694,0.00002435739,0.00009922437,0.001321321,0.001090493,0.9882233,0.0001584523,0.007467831,0.0001382413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973633,0.00142901,0.000009358169,0.0002662016,0.0002838608,0.000289225,0.00001779684,0.000005494732,0.0003357138],"genre_scores_gemma":[0.9987983,0.00009719688,0.00003234708,0.000232737,0.0000217966,0.00001964168,0.0000119869,0.00002493057,0.0007610665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007020754,"threshold_uncertainty_score":0.3611557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002592884249592263,"score_gpt":0.1745386566193292,"score_spread":0.1719457723697369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}