{"id":"W4308052558","doi":"10.1139/cjpp-2022-0307","title":"Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metformin; PI3K/AKT/mTOR pathway; Mitochondrion; Apoptosis; Endocrinology; Internal medicine; Cell biology; Chemistry; Cancer research; Cell growth; Biology; Medicine; Signal transduction; Diabetes mellitus; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303831,0.0002112203,0.0002963027,0.000280305,0.0001712231,0.0002863712,0.0001427737,0.0002640895,0.001253717],"category_scores_gemma":[0.000218469,0.000139692,0.0002354153,0.000189853,0.0001878664,0.0001881532,0.0002043792,0.0005278941,0.0001522721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629338,"about_ca_system_score_gemma":0.000307636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005767294,"about_ca_topic_score_gemma":0.001629068,"domain_scores_codex":[0.9998497,0.00003024692,0.00001877404,0.00002275289,0.00004814177,0.00003025615],"domain_scores_gemma":[0.9999223,0.00001817681,0.00002489245,0.000005651734,0.00001478177,0.0000141551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007731519,0.00008694439,0.0005582819,0.0002428962,0.00001501539,0.0000905334,0.0000357152,0.0001350134,0.9910197,0.0001512477,0.0001372652,0.00675431],"study_design_scores_gemma":[0.0001539878,0.002763993,0.02747622,0.00003882494,0.00009478853,0.0003836037,0.0001691933,0.001450147,0.9589748,0.0002261829,0.008248725,0.00001952272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985546,0.009747446,0.001638699,0.0003163817,0.00008207119,0.00004494798,0.0004570523,0.0000738515,0.002093493],"genre_scores_gemma":[0.9915941,0.004420847,0.00225708,0.0001601404,0.00002492193,0.00005983496,0.0003766623,0.00001234244,0.001094096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253717,"threshold_uncertainty_score":0.00419414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00915860467408983,"score_gpt":0.2470094101109835,"score_spread":0.2378508054368936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}