{"id":"W4308057718","doi":"10.1007/s00262-022-03313-2","title":"Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canada Research Chairs; Cancer Research Society","keywords":"CCL20; Radioresistance; Cancer research; Head and neck squamous-cell carcinoma; Immune system; Chemokine; Tumor microenvironment; Medicine; Flow cytometry; Immunotherapy; Immunology; Biology; Radiation therapy; Head and neck cancer; Internal medicine; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169173,0.000296024,0.0003315804,0.0002463909,0.0002097249,0.0003787551,0.0002774516,0.0002953283,0.0036686],"category_scores_gemma":[0.0001348563,0.0001405777,0.0002981437,0.0001313288,0.0002655757,0.0002046835,0.000191761,0.0009702168,0.0007570981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308604,"about_ca_system_score_gemma":0.0005047041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009329368,"about_ca_topic_score_gemma":0.002606276,"domain_scores_codex":[0.9997692,0.00002966844,0.00001085236,0.00002407027,0.00005567562,0.0001105938],"domain_scores_gemma":[0.9999266,0.00000862759,0.00001332939,0.00001430372,0.000007692991,0.00002940476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005905766,0.000443565,0.0004244449,0.0000573715,0.00001555819,0.00006129501,0.00002945598,0.000333276,0.9912777,0.0003683728,0.0006451461,0.00575316],"study_design_scores_gemma":[0.0001836758,0.003818315,0.006201754,0.00001081859,0.00003609234,0.0003682334,0.00007575448,0.002168825,0.9780949,0.000121306,0.008907646,0.00001276572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994297,0.001230322,0.0008168222,0.0002032697,0.0001260565,0.00006517648,0.0002681316,0.000191091,0.00280211],"genre_scores_gemma":[0.9952782,0.0005233477,0.0005587667,0.0000728322,0.00002052885,0.00003824315,0.0002822695,0.00002132402,0.003204431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0036686,"threshold_uncertainty_score":0.01227272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227204180793131,"score_gpt":0.2710689946598808,"score_spread":0.2483485765805677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}