{"id":"W4308101961","doi":"10.1371/journal.pgen.1010367","title":"Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Fondation de l'Hôpital général juif; Rheinische Friedrich-Wilhelms-Universität Bonn; Fondation Leenaards; Technische Universität München; King Abdulaziz City for Science and Technology; Jewish General Hospital; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; National Science and Technology Development Agency; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agencja Badań Medycznych; McGill University; Japan Agency for Medical Research and Development; Dipartimenti di Eccellenza; Deutsche Forschungsgemeinschaft; University of Pennsylvania; Public Health Agency; European Commission; Ministero dell’Istruzione, dell’Università e della Ricerca; British Heart Foundation; Thailand Research Fund; Public Health Agency of Canada; Bundesministerium für Bildung und Forschung; NHS Blood and Transplant; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Cancer Research UK; National Heart, Lung, and Blood Institute; University of Pennsylvania Health System; Università degli Studi di Siena; Science for Life Laboratory; National Science Foundation; Compute Canada; Dr. Rolf M. Schwiete Stiftung; National Center for Global Health and Medicine; Japan Science and Technology Agency; Vetenskapsrådet; Georgia Clinical and Translational Science Alliance; Chulalongkorn University; Health Systems Research Institute; Qatar Foundation","keywords":"Biology; Exome; Coronavirus disease 2019 (COVID-19); Genetics; Exome sequencing; Human genetics; Genome-wide association study; Host (biology); 2019-20 coronavirus outbreak; Evolutionary biology; Computational biology; Genotype; Mutation; Virology; Single-nucleotide polymorphism; Disease; Gene; Medicine; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005553564,0.0003361016,0.0002726411,0.00008084696,0.0007170379,0.0001177822,0.0008279782,0.00009615709,0.00007139897],"category_scores_gemma":[0.00211599,0.0003182848,0.000108173,0.0003639665,0.00003478887,0.000004562374,0.001358509,0.0002796872,0.00003727382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453169,"about_ca_system_score_gemma":0.000388684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007777361,"about_ca_topic_score_gemma":0.0004892541,"domain_scores_codex":[0.9966928,0.0005475673,0.0006294778,0.0008226841,0.0008279064,0.0004795781],"domain_scores_gemma":[0.9980765,0.0003664304,0.0003300421,0.0008039161,0.0001631547,0.0002599689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002267112,0.0008323421,0.7985673,0.000009598776,0.0005772274,0.00002756622,0.0105056,0.006854273,0.1705535,0.000001357299,0.01172043,0.0001240689],"study_design_scores_gemma":[0.002398375,0.0008669923,0.9517804,0.000005851385,0.0001466195,0.000001550529,0.009985364,0.0001114855,0.0168991,0.0001009223,0.01714032,0.0005630389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942285,0.0003938173,0.0001242094,0.002150169,0.0004258104,0.001235056,0.001215587,0.00002807916,0.0001988157],"genre_scores_gemma":[0.9818301,0.0001664162,0.0003671224,0.01658903,0.00006696479,0.0001800255,0.0004862678,0.00006531168,0.0002487325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1536544,"threshold_uncertainty_score":0.9999269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042388599608554,"score_gpt":0.3013149609602753,"score_spread":0.2589263613517213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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