{"id":"W4308101961","doi":"10.1371/journal.pgen.1010367","title":"Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Fondation de l'Hôpital général juif; Rheinische Friedrich-Wilhelms-Universität Bonn; Fondation Leenaards; Technische Universität München; King Abdulaziz City for Science and Technology; Jewish General Hospital; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; National Science and Technology Development Agency; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agencja Badań Medycznych; McGill University; Japan Agency for Medical Research and Development; Dipartimenti di Eccellenza; Deutsche Forschungsgemeinschaft; University of Pennsylvania; Public Health Agency; European Commission; Ministero dell’Istruzione, dell’Università e della Ricerca; British Heart Foundation; Thailand Research Fund; Public Health Agency of Canada; Bundesministerium für Bildung und Forschung; NHS Blood and Transplant; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Cancer Research UK; National Heart, Lung, and Blood Institute; University of Pennsylvania Health System; Università degli Studi di Siena; Science for Life Laboratory; National Science Foundation; Compute Canada; Dr. Rolf M. Schwiete Stiftung; National Center for Global Health and Medicine; Japan Science and Technology Agency; Vetenskapsrådet; Georgia Clinical and Translational Science Alliance; Chulalongkorn University; Health Systems Research Institute; Qatar Foundation","keywords":"Biology; Exome; Coronavirus disease 2019 (COVID-19); Genetics; Exome sequencing; Human genetics; Genome-wide association study; Host (biology); 2019-20 coronavirus outbreak; Evolutionary biology; Computational biology; Genotype; Mutation; Virology; Single-nucleotide polymorphism; Disease; Gene; Medicine; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003351674,0.0008639111,0.0008248499,0.001204663,0.0006609342,0.001448268,0.0004773165,0.000760849,0.004279655],"category_scores_gemma":[0.007866064,0.0002634969,0.002165202,0.002068984,0.0004288825,0.0004934088,0.001651091,0.001176333,0.0004318925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308448,"about_ca_system_score_gemma":0.0004632185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003322382,"about_ca_topic_score_gemma":0.004509435,"domain_scores_codex":[0.997957,0.0007301441,0.0002008115,0.0006770805,0.0002604236,0.0001745802],"domain_scores_gemma":[0.995188,0.00251988,0.0007363835,0.0005857919,0.0005182491,0.0004517733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00260793,0.00006643702,0.941624,0.0004353155,0.01038701,0.001834556,0.0003994157,0.001042648,0.008467251,0.001439867,0.003486771,0.02820889],"study_design_scores_gemma":[0.0001930078,0.0002645518,0.9788232,0.0002197258,0.004270654,0.001982835,0.0002363703,0.001336483,0.00153338,0.00154289,0.009540678,0.00005608314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662083,0.01038998,0.008349029,0.001733937,0.0001720026,0.00006231578,0.01003025,0.00007071572,0.002983427],"genre_scores_gemma":[0.984983,0.003086567,0.003278694,0.0006254105,0.0001290414,0.0000776915,0.006748957,0.00007102011,0.0009995723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004279655,"threshold_uncertainty_score":0.01772553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042388599608554,"score_gpt":0.3013149609602753,"score_spread":0.2589263613517213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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