{"id":"W4308108258","doi":"10.1016/j.ccell.2022.10.002","title":"Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Merck Sharp and Dohme; Fonds de recherche du Québec; Wellcome Trust; Francis Crick Institute; Cancer Research UK","keywords":"Phenotype; Biology; Cancer cell; Cancer; Cell biology; Genetics; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009563955,0.0001467682,0.0002142723,0.0001726116,0.0001222255,0.0003856606,0.0001558505,0.0001847606,0.001196879],"category_scores_gemma":[0.0001973727,0.000103463,0.0001173644,0.0001152883,0.0002399038,0.0001602215,0.0006087451,0.0004302847,0.0002526454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868848,"about_ca_system_score_gemma":0.0001562788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738033,"about_ca_topic_score_gemma":0.0003978373,"domain_scores_codex":[0.9998873,0.00001708147,0.000007126254,0.00003036589,0.0000337989,0.00002415471],"domain_scores_gemma":[0.999791,0.000045263,0.00005222987,0.00004245437,0.00001687232,0.00005222833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003955215,0.000009841843,0.001513878,0.00001046375,0.000004389824,0.00007293113,0.0000192894,0.0001452067,0.9957332,0.0003799201,0.00002976904,0.002041564],"study_design_scores_gemma":[0.00002831101,0.0005197034,0.05791401,0.000008133649,0.00004909885,0.002105491,0.0001317252,0.006466407,0.9266011,0.0008991285,0.005254889,0.00002201569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950728,0.0002590266,0.003122167,0.00007879618,0.00000694512,0.000009491205,0.00007058962,0.00008673931,0.001293432],"genre_scores_gemma":[0.9985759,0.00008256156,0.0006203335,0.00004335545,0.000003133269,0.000005710509,0.00006140194,0.00001360251,0.0005939516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196879,"threshold_uncertainty_score":0.004004002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004714068063583013,"score_gpt":0.2378002136815178,"score_spread":0.2330861456179348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}