{"id":"W4308119967","doi":"10.3389/fonc.2022.951267","title":"Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Downregulation and upregulation; Cetuximab; Antibody; Polyclonal antibodies; Monoclonal antibody; Epitope; Cytotoxicity; Cancer research; Immunology; Biology; Pharmacology; Molecular biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538,0.0005046338,0.00044436,0.000228952,0.00008822566,0.0002953683,0.000198403,0.0002569719,0.001878088],"category_scores_gemma":[0.0001560399,0.0001344842,0.0003480841,0.0001797013,0.0001486847,0.000202116,0.0001917667,0.0006817618,0.0003905285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247731,"about_ca_system_score_gemma":0.0002082775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002177262,"about_ca_topic_score_gemma":0.0003678114,"domain_scores_codex":[0.9997236,0.00004733396,0.00002178217,0.0000613321,0.00006727577,0.00007855035],"domain_scores_gemma":[0.9998494,0.0000488646,0.00003145619,0.0000200917,0.00002163361,0.00002842719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009269308,0.00009129073,0.0001149221,0.00004276308,0.000008309662,0.00001460245,0.000004558716,0.0000580561,0.9978262,0.00004368809,0.00003998426,0.001662856],"study_design_scores_gemma":[0.0000215006,0.0009521815,0.001481376,0.000004569455,0.00002994133,0.0001651726,0.000003995235,0.0006224041,0.9953459,0.00001421853,0.001356813,0.00000204651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922087,0.002063477,0.003268294,0.00004570743,0.00003288185,0.00003917169,0.0001067502,0.000118399,0.002116621],"genre_scores_gemma":[0.9956912,0.0008024918,0.001784896,0.00004486022,0.00002453702,0.00003377751,0.0002722469,0.00002347008,0.001322509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878088,"threshold_uncertainty_score":0.006282806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02679545680241373,"score_gpt":0.3485464060881204,"score_spread":0.3217509492857067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}