{"id":"W4308183420","doi":"10.1073/pnas.2206333119","title":"Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Immunogenicity; Virology; Hemagglutinin (influenza); Nucleoprotein; Neuraminidase; Virus; Antigen; Biology; Influenza A virus; Vaccination; Influenza vaccine; Immune system; Antigenic drift; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003191857,0.000477389,0.0002878433,0.0001739938,0.00009730498,0.0002467953,0.0002376593,0.0004980189,0.0005339879],"category_scores_gemma":[0.0002229861,0.0001562086,0.000180046,0.00009478583,0.0002133185,0.00028198,0.0001480323,0.0005033452,0.0001087676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179732,"about_ca_system_score_gemma":0.0002254002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459966,"about_ca_topic_score_gemma":0.0007810553,"domain_scores_codex":[0.9998084,0.00004657812,0.00001438035,0.00003603235,0.00005830161,0.00003635865],"domain_scores_gemma":[0.9999142,0.00001966504,0.0000223088,0.000007989922,0.00001824354,0.0000176221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001830872,0.0001694957,0.0001627731,0.00003533394,0.00001006481,0.00001471842,0.000009984432,0.0004060658,0.9973933,0.00002662883,0.00001448247,0.001573978],"study_design_scores_gemma":[0.0001186221,0.01820271,0.002705874,0.000006785256,0.00008459126,0.0001543778,0.00002903147,0.002589674,0.9750223,0.00004012676,0.001036666,0.000009112396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973165,0.000389118,0.001716061,0.00003156998,0.00001768289,0.00009364864,0.0000884801,0.00001745019,0.0003294267],"genre_scores_gemma":[0.9951499,0.0004219993,0.003495329,0.00003827646,0.00001109151,0.00008141913,0.0002447514,0.000007190686,0.0005500518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005459966,"threshold_uncertainty_score":0.002307117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1709195734833343,"score_gpt":0.4255608625779924,"score_spread":0.2546412890946581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}