{"id":"W4308184058","doi":"10.1093/eurheartj/ehac594","title":"Inclisiran and cardiovascular events: a patient-level analysis of phase III trials","year":2022,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novartis Pharma","keywords":"Medicine; Mace; Myocardial infarction; Internal medicine; Placebo; Stroke (engine); Clinical endpoint; Statin; Cardiology; Surrogate endpoint; Randomized controlled trial; Surgery; Percutaneous coronary intervention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01207733,0.0001509174,0.001462244,0.0005507263,0.0003985933,0.00002107398,0.00009817738,0.00002032305,0.0005826993],"category_scores_gemma":[0.0003331706,0.0001227593,0.002221806,0.000782132,0.00003611844,0.00006920809,0.0001722593,0.0005024521,0.000003508012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006928133,"about_ca_system_score_gemma":0.0001358798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006604172,"about_ca_topic_score_gemma":0.000001104152,"domain_scores_codex":[0.994172,0.003229072,0.0008917315,0.0002631723,0.00118622,0.0002577431],"domain_scores_gemma":[0.998633,0.00006475914,0.0002753711,0.0005669884,0.0001348164,0.000325099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003373297,0.002188073,0.03011724,0.0002313671,0.09629282,0.002732326,0.005682583,0.002395819,0.004544157,0.00006199912,0.008185259,0.8441951],"study_design_scores_gemma":[0.0520458,0.006935742,0.2627191,0.0002135081,0.037455,0.009654182,0.003910793,0.0006984863,0.0005955937,0.00004079192,0.6250471,0.0006839313],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98536,0.01157004,0.001194652,0.0002534177,0.000241943,0.0004563826,0.00008504998,0.00001755394,0.0008209908],"genre_scores_gemma":[0.9979424,0.0004497311,0.0005918494,0.0004909888,0.0003821894,0.000006913945,0.00002565261,0.00003365536,0.00007657848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8435111,"threshold_uncertainty_score":0.6380148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09547442155195424,"score_gpt":0.3419514957216955,"score_spread":0.2464770741697412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}