{"id":"W4308184069","doi":"10.1093/ndt/gfac289","title":"Design and population of the VALOR-CKD study: a multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of veverimer in slowing progression of chronic kidney disease in patients with metabolic acidosis","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal function and acid-base balance","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Kidney disease; Renal function; Internal medicine; Population; Creatinine; Metabolic acidosis; Placebo; Diabetes mellitus; Randomized controlled trial; Clinical endpoint; Gastroenterology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001817465,0.0001279449,0.0007519606,0.0002116544,0.00009363599,0.000003963744,0.00005978963,0.00003798672,0.00001463201],"category_scores_gemma":[0.00017577,0.00007135106,0.00009521322,0.0003788458,0.0001026899,0.00007262655,0.00001672358,0.0001561638,4.563851e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003288157,"about_ca_system_score_gemma":0.0001213311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001591686,"about_ca_topic_score_gemma":0.00003312791,"domain_scores_codex":[0.9966553,0.001899743,0.0006989777,0.0002190388,0.0004140783,0.0001128611],"domain_scores_gemma":[0.9985683,0.0007182797,0.0004548022,0.0001562207,0.00006337095,0.00003902709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.780453,0.0008219671,0.2047486,0.00006591173,0.0002734777,8.711286e-7,0.001587865,0.008828591,0.002236209,0.000004646418,1.801289e-7,0.0009787008],"study_design_scores_gemma":[0.6841859,0.001033311,0.3011618,0.00008658419,0.002015394,3.707983e-7,0.00003830019,0.01107823,0.0003549907,0.000003068965,3.162852e-7,0.00004173212],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900079,0.0002473385,0.0003114829,0.0001205917,0.00007416273,0.009222757,0.00000868636,0.000005096304,0.000002012047],"genre_scores_gemma":[0.9988677,0.00008412412,0.0001026558,0.00005508527,0.00001574118,0.0007832647,0.00008033837,0.000009137371,0.000001985036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09641318,"threshold_uncertainty_score":0.2909612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776119792414823,"score_gpt":0.3012167709621455,"score_spread":0.2834555730379973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}