{"id":"W4308184069","doi":"10.1093/ndt/gfac289","title":"Design and population of the VALOR-CKD study: a multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of veverimer in slowing progression of chronic kidney disease in patients with metabolic acidosis","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal function and acid-base balance","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Kidney disease; Renal function; Internal medicine; Population; Creatinine; Metabolic acidosis; Placebo; Diabetes mellitus; Randomized controlled trial; Clinical endpoint; Gastroenterology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004649417,0.002428461,0.004245301,0.0005874671,0.0007743292,0.001668519,0.0009173803,0.00302449,0.009319192],"category_scores_gemma":[0.004398916,0.0009305466,0.001716264,0.0006275343,0.001536271,0.00165795,0.0006057131,0.002482662,0.001395984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006059555,"about_ca_system_score_gemma":0.001737256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005847876,"about_ca_topic_score_gemma":0.001028974,"domain_scores_codex":[0.9972436,0.001521476,0.000199139,0.0005797677,0.0001755097,0.0002804894],"domain_scores_gemma":[0.9983698,0.0003309479,0.0004681891,0.0001397205,0.0001758149,0.000515641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9899469,0.002932479,0.0008721033,0.000500135,0.000676412,0.00001943219,0.00002355641,0.0001093179,0.0007860461,0.0001281287,0.0004563554,0.003549034],"study_design_scores_gemma":[0.9829979,0.01465998,0.001207235,0.00003541192,0.000384808,0.00001187764,0.000008720466,0.0001004919,0.00009546067,0.00009809122,0.0003912055,0.000008772725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8969787,0.01371882,0.003440852,0.002459714,0.002133847,0.06848791,0.005342633,0.0003199012,0.007117589],"genre_scores_gemma":[0.8962819,0.003541982,0.007118086,0.003482888,0.001510904,0.08142365,0.002592099,0.00004704803,0.004001501],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.009319192,"threshold_uncertainty_score":0.03117579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776119792414823,"score_gpt":0.3012167709621455,"score_spread":0.2834555730379973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}