{"id":"W4308192864","doi":"10.1371/journal.pone.0276541","title":"All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Children's Hospital; Alberta Medical Association; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Retinoic acid; Cardiotoxicity; Anthracycline; Doxorubicin; Biology; Retinoic acid receptor; Tretinoin; Cancer research; Cell biology; Pharmacology; Molecular biology; Biochemistry; Gene; Genetics; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009475479,0.0002376882,0.0005539536,0.0001432803,0.000278557,0.00003917805,0.0002013081,0.0001347094,0.00008645331],"category_scores_gemma":[0.00009673958,0.0002017005,0.000157861,0.0003765052,0.0001066535,0.0001175678,0.00006070043,0.0006267998,0.000002870886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129644,"about_ca_system_score_gemma":0.0001018742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007232827,"about_ca_topic_score_gemma":0.00001828852,"domain_scores_codex":[0.9976516,0.0003705943,0.0003792246,0.0004672282,0.0007742377,0.0003571116],"domain_scores_gemma":[0.9991106,0.0001375675,0.0001105348,0.0004746038,0.00006081447,0.0001058255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002148861,0.0007930985,0.001819579,0.0001121038,0.0002959481,0.00006486905,0.003805467,0.000008568499,0.9901159,0.0000493907,0.00006858914,0.002651575],"study_design_scores_gemma":[0.001709877,0.000362138,0.01131639,0.0001238472,0.0002192833,0.0001069639,0.001611066,0.0001319613,0.9833965,0.0001994846,0.0005946552,0.0002277948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892334,0.001356716,0.000005261344,0.006839467,0.00008448717,0.001054134,0.00003718414,0.00009391595,0.001295422],"genre_scores_gemma":[0.9966014,0.0007167198,0.0003889618,0.001423992,0.0004468648,0.0001879549,0.00007753442,0.0000402424,0.0001163203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00949681,"threshold_uncertainty_score":0.822511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05351442938724601,"score_gpt":0.2564913656507182,"score_spread":0.2029769362634722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}