{"id":"W4308192864","doi":"10.1371/journal.pone.0276541","title":"All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; BC Children's Hospital; Alberta Medical Association; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Retinoic acid; Cardiotoxicity; Anthracycline; Doxorubicin; Biology; Retinoic acid receptor; Tretinoin; Cancer research; Cell biology; Pharmacology; Molecular biology; Biochemistry; Gene; Genetics; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488112,0.0002952325,0.0003376791,0.0003315292,0.0001158481,0.000206493,0.0001521834,0.0002454703,0.001132101],"category_scores_gemma":[0.0001039608,0.000103027,0.0002716737,0.0001327576,0.0001468187,0.00013549,0.0001332221,0.0004419873,0.0003018585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001450302,"about_ca_system_score_gemma":0.0001539942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000391869,"about_ca_topic_score_gemma":0.001012081,"domain_scores_codex":[0.9998482,0.00003489105,0.00001473461,0.0000240099,0.00004355239,0.00003458504],"domain_scores_gemma":[0.9998996,0.00000931747,0.00003475688,0.00001144755,0.00001458903,0.00003024139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075554,0.0000268582,0.0001651685,0.00002899213,0.000009447961,0.00001994647,0.000005764478,0.00003606763,0.9982536,0.00001862362,0.00002755965,0.001300365],"study_design_scores_gemma":[0.00004265716,0.001311332,0.009864348,0.00001120767,0.00004765685,0.0002155207,0.0000428202,0.0003894722,0.9846764,0.00003997048,0.003353165,0.000005416964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98666,0.00775747,0.002886102,0.0001614656,0.0000557842,0.00004802633,0.0004407071,0.0001677082,0.001822746],"genre_scores_gemma":[0.9914364,0.003483308,0.001894103,0.00007447883,0.00001600364,0.00003434491,0.00044599,0.0000249779,0.002590305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132101,"threshold_uncertainty_score":0.003787279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05351442938724601,"score_gpt":0.2564913656507182,"score_spread":0.2029769362634722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}