{"id":"W4308200450","doi":"10.1101/2022.11.02.514865","title":"Apoptotic contraction drives target cell release by cytotoxic T cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Ludwig Institute for Cancer Research; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Cancer Research Institute","keywords":"Cytotoxic T cell; CTL*; Cell biology; Contraction (grammar); Immunological synapse; Contractility; Apoptosis; Cytoskeleton; Stimulation; Cell; Biology; Immune system; Chemistry; T cell; Neuroscience; Immunology; T-cell receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009896258,0.0001437105,0.0002144626,0.0001000734,0.0001096362,0.0003182373,0.0001522515,0.0002120185,0.001347842],"category_scores_gemma":[0.0001217826,0.0001034052,0.000115848,0.00008061378,0.0001703795,0.0001553295,0.0002721538,0.0005243401,0.0003466921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506435,"about_ca_system_score_gemma":0.00009799254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001873828,"about_ca_topic_score_gemma":0.0002311205,"domain_scores_codex":[0.9998822,0.00001210609,0.000005269327,0.00002479289,0.00003986472,0.00003575792],"domain_scores_gemma":[0.9999228,0.00001865636,0.00001870074,0.000009172056,0.00001033351,0.00002034048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005164746,0.00001170676,0.0001643632,0.00001288909,0.000001491378,0.00003939942,0.00001280635,0.00005999072,0.9983844,0.0001030254,0.00004074689,0.001117563],"study_design_scores_gemma":[0.00002850054,0.0002045694,0.007393493,0.000007858132,0.000005566424,0.000196218,0.00006444464,0.004527648,0.9857969,0.0001573928,0.001613249,0.00000418319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960854,0.0005186836,0.001984531,0.00009627734,0.00001956636,0.00000925345,0.00006143496,0.00002729096,0.001197481],"genre_scores_gemma":[0.9977524,0.0001519352,0.0006949933,0.00005686246,0.00001170959,0.00001113867,0.00007329239,0.000009852597,0.001237895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347842,"threshold_uncertainty_score":0.004508972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293186622221055,"score_gpt":0.2478497592762781,"score_spread":0.2349178930540676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}